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TH-030418

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TH-030418
Names

IUPAC name 7α-[(R)-1-hydroxy-1-methyl-3-(thiophen-3-yl)-propyl]-6,14-endo-ethanotetrahydrooripavine
Identifiers
CAS Number	1374406-56-0
3D model (JSmol)	Interactive image
InChI InChI=1S/C28H35NO4S/c1-25(31,9-8-18-5-4-14-34-18)20-16-26-10-11-28(20,32-3)24-27(26)12-13-29(2)21(26)15-17-6-7-19(30)23(33-24)22(17)27/h4-7,14,20-21,24,30-31H,8-13,15-16H2,1-3H3/t20?,21-,24-,25?,26?,27+,28?/m1/s1 Key: XHPBFKQABAJWQT-ZAEBSCISSA-N
SMILES OC1=C(O[C@H]2C(OC)(CC6)C(C(O)(C)CCC7=CC=CS7)CC36[C@@]42CCN5C)C4=C(C[C@H]35)C=C1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

TH-030418 is an extremely potentopioid related tothienorphine. TH-030418 carries about 5,000 times the potency ofmorphine.^[1]^[2]

^Yu, G; Yan, LD; Li, YL; Wen, Q; Dong, HJ; Gong, ZH (August 2011). "TH-030418: a potent long-acting opioid analgesic with low dependence liability".Naunyn-Schmiedeberg's Archives of Pharmacology.384 (2):125–31.doi:10.1007/s00210-011-0652-8.PMID 21594658.
^Wen, Q; Yu, G; Li, YL; Yan, LD; Gong, ZH (October 2011)."Pharmacological mechanisms underlying the antinociceptive and tolerance effects of the 6,14-bridged oripavine compound 030418".Acta Pharmacologica Sinica.32 (10):1215–24.doi:10.1038/aps.2011.83.PMC 4010084.PMID 21863064.