Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrialenzyme that is encoded by theTFB1Mgene.[5][6][7]
TFB1M is a mitochondrial methyltransferase, which usesS-adenosyl methionine to dimethylate two highly conservedadenosine residues at the 3'-end of the mitochondrial12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.[6][8][9]
Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in anin vitro system containing recombinant mitochondrial RNA polymerase andTFAM.[10] There are no experimental data demonstrating that this function occursin vivo; the paralogousTFB2M is more specific for this role.[11]
^Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA".Nat. Genet.31 (3):289–94.doi:10.1038/ng909.PMID12068295.S2CID11164308.
Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA".Nat. Genet.31 (3):289–94.doi:10.1038/ng909.PMID12068295.S2CID11164308.
Rantanen A, Gaspari M, Falkenberg M, et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2".Mamm. Genome.14 (1):1–6.doi:10.1007/s00335-002-2218-z.PMID12532263.S2CID25379746.
Bykhovskaya Y, Mengesha E, Wang D, et al. (2004). "Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation".Mol. Genet. Metab.82 (1):27–32.doi:10.1016/j.ymgme.2004.01.020.PMID15110318.
