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TEAD3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
TEAD3
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

5EMW

Identifiers
AliasesTEAD3, DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5, TEA domain transcription factor 3
External IDsOMIM:603170;MGI:109241;HomoloGene:81821;GeneCards:TEAD3;OMA:TEAD3 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TEAD3
Genomic location for TEAD3
Band6p21.31Start35,473,597bp[1]
End35,497,079bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for TEAD3
Genomic location for TEAD3
Band17 A3.3|17 14.66 cMStart28,550,645bp[2]
End28,569,791bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle layer of sigmoid colon

  • gastric mucosa

  • body of uterus

  • left uterine tube

  • popliteal artery

  • tibial arteries

  • right coronary artery

  • thoracic aorta

  • ascending aorta

  • ectocervix
Top expressed in
  • lip

  • genital tubercle

  • esophagus

  • trophoblast giant cell

  • ventricular zone

  • muscle of thigh

  • neural layer of retina

  • urethra

  • female urethra

  • molar
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7005

21678

Ensembl

ENSG00000007866

ENSMUSG00000002249

UniProt

Q99594

P70210

RefSeq (mRNA)

NM_003214
NM_001395214

NM_001098226
NM_001204156
NM_011566

RefSeq (protein)

NP_003205

NP_001091696
NP_001191085
NP_035696

Location (UCSC)Chr 6: 35.47 – 35.5 MbChr 17: 28.55 – 28.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcriptional enhancer factor TEF-5 is aprotein that in humans is encoded by theTEAD3gene.[5][6][7]

Function

[edit]

This gene product is a member of the transcriptional enhancer factor (TEF) family oftranscription factors, which contain the TEA/ATTS DNA-binding domain.[8] Members of the family in mammals areTEAD1,TEAD2, TEAD3,TEAD4. Transcriptional coregulators, such asWWTR1 (TAZ) bind to these transcription factors. TEAD3 is predominantly expressed in theplacenta and is involved in thetransactivation of thechorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.[9] Translation of this protein is initiated at a non-AUG (AUA)start codon.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000007866 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000002249 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis".Genomics.55 (1):127–9.doi:10.1006/geno.1998.5628.hdl:2268/13836.PMID 9889009.
  6. ^Jacquemin P, Martial JA, Davidson I (May 1997)."Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer".The Journal of Biological Chemistry.272 (20):12928–37.doi:10.1074/jbc.272.20.12928.PMID 9148898.
  7. ^ab"Entrez Gene: TEAD3 TEA domain family member 3".
  8. ^Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif".Cell.66 (1):11–12.doi:10.1016/0092-8674(91)90132-I.PMID 2070413.S2CID 2819591.
  9. ^Mann CJ, Osborn DP, Hughes SM (Oct 2007)."Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord".Gene Expression Patterns.7 (8):827–36.doi:10.1016/j.modgep.2007.08.001.PMC 3360971.PMID 17916448.

Further reading

[edit]

External links

[edit]
PDB gallery
  • 2hzd: NMR structure of the DNA-binding TEA domain and insights into TEF-1 function
    2hzd: NMR structure of the DNA-binding TEA domain and insights into TEF-1 function
(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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