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TA-NIC is a proprietaryvaccine in development similar toTA-CD but being used to create human anti-nicotineantibodies in a person to destroynicotine in the human body so that it is no longer effective.[1]
TA-NIC is a vaccine in development as an aid toquitting smoking in motivated patients. TA-NIC is an immunotherapeutic vaccine similar in concept to TA-CD, designed to raise anti-nicotine antibodies. The antibodies bind to nicotine molecules in the patient's blood stream, reducing the rate and quantity of nicotine entry into thebrain and thus reducing thepositive reinforcement andaddiction associated with nicotine andcigarette smoking. It is expected that the reduction of the positive reinforcement will in turn reduce the desire to smoke or use othertobacco products.Treatment with TA-NIC is expected to be part of a comprehensive smoking cessation management program that includes other supportive measures.
Results from its clinical trials are not publicly available, although one of its developers, Thomas Kosten, disclosed in an email that the vaccine was not found to be effective enough to continue development.[2]
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