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Syntaxin binding protein 3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
STXBP3
Identifiers
AliasesSTXBP3, MUNC18-3, MUNC18C, PSP, UNC-18C, Syntaxin binding protein 3
External IDsOMIM:608339;MGI:107362;HomoloGene:5260;GeneCards:STXBP3;OMA:STXBP3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for STXBP3
Genomic location for STXBP3
Band1p13.3Start108,746,674bp[1]
End108,809,523bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for STXBP3
Genomic location for STXBP3
Band3|3 F3Start108,700,492bp[2]
End108,747,842bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • Achilles tendon

  • tibia

  • C1 segment

  • germinal epithelium

  • epithelium of nasopharynx

  • inferior ganglion of vagus nerve

  • monocyte

  • sural nerve

  • palpebral conjunctiva
Top expressed in
  • skin of external ear

  • stroma of bone marrow

  • Epithelium of choroid plexus

  • ascending aorta

  • sciatic nerve

  • jejunum

  • aortic valve

  • retinal pigment epithelium

  • transitional epithelium of urinary bladder

  • lumbar subsegment of spinal cord
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6814

20912

Ensembl

ENSG00000116266

ENSMUSG00000027882

UniProt

O00186

Q60770

RefSeq (mRNA)

NM_007269

NM_011504

RefSeq (protein)

NP_009200

NP_035634

Location (UCSC)Chr 1: 108.75 – 108.81 MbChr 3: 108.7 – 108.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Syntaxin-binding protein 3 is aprotein that in humans is encoded by theSTXBP3gene.[5][6]

Interactions

[edit]

Syntaxin binding protein 3 has been shown tointeract withSTX2[7] andSTX4.[7][8]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000116266 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000027882 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Reed GL, Houng AK, Fitzgerald ML (April 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion".Blood.93 (8):2617–26.doi:10.1182/blood.V93.8.2617.PMID 10194441.
  6. ^"Entrez Gene: STXBP3 syntaxin binding protein 3".
  7. ^abSchraw TD, Lemons PP, Dean WL, Whiteheart SW (August 2003)."A role for Sec1/Munc18 proteins in platelet exocytosis".The Biochemical Journal.374 (Pt 1):207–17.doi:10.1042/BJ20030610.PMC 1223584.PMID 12773094.
  8. ^Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003)."Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation".The Journal of Biological Chemistry.278 (37):35093–101.doi:10.1074/jbc.M304261200.PMID 12832401.

Further reading

[edit]
PDB gallery
  • 2pjx: Crystal structure of the Munc18c/Syntaxin4 N-peptide complex
    2pjx: Crystal structure of the Munc18c/Syntaxin4 N-peptide complex
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