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| Names | |
|---|---|
| IUPAC name 4-[1-Hydroxy-2-[4-(4-methoxyphenyl)butan-2-ylamino]ethyl]-2-methylsulfinylphenol | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| UNII | |
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| Properties | |
| C20H27NO4S | |
| Molar mass | 377.50 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Sulfinalol is abeta adrenergic receptor antagonist.[1]
The preparation of sulfinalol begins by protection of the phenolic hydroxyl as its benzoate ester. Bromination followed bycondensation with 4-(4-methoxyphenyl)butan-2-amine gives the amino ketone3. Successive catalytic reduction andsaponification affordsamino alcohol4. Oxidation of thesulfide to thesulfoxide with a reagent such asmetaperiodate gives sulfinalol (5).
The methyl group on a sulfoxide is sufficiently acidic to substitute for phenolic hydroxyl.
