Thesubstituted benzothiophenes are a class ofchemical compounds based onbenzothiophene.^[1][2] They are closely related to thesubstituted benzofurans,substituted tryptamines, and to otherchemical groups such as thesubstituted benzodioxoles (ormethylenedioxyphenyl compounds).^[1][2]

Substituted benzothiophenes include the (2-aminopropyl)benzo[β]thiophenes (APBTs)2-APBT,3-APBT (SKF-6678),4-APBT,5-APBT,5-MAPBT,6-APBT, and7-APBT.^[1][2] These drugs have been found to act asserotonin–norepinephrine–dopamine releasing agents (SNDRAs) and, in some cases, aspotentserotonin5-HT₂ receptoragonists, analogously to the entactogenMDMA.^[2] They do not producehyperlocomotion in rodents, suggesting that they lackpsychostimulant effects.^[2] However, those acting as serotonin 5-HT₂ receptor agonists have been found to induce thehead-twitch response, a behavioral proxy ofpsychedelic effects, in rodents.^[2]

These findings suggest that substituted benzothiophenes may have entactogenic and/or psychedelic effects in humans whilst lacking stimulant effects and possibly having reducedmisuse potential.^[2] The substituted benzothiophenes have been little-encountered asdesigner drugs as of 2022.^[1][2]

Tactogen haspatented a number of benzothiophenes as novel entactogens for use as potential medicines.^[3][4][5]

• Substituted methylenedioxyphenethylamine § Related compounds

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