Species of bacterium
Streptomyces cattleya Gram-positive bacterium which makescephamycin ,[ 1] penicillin andthienamycin .[ 2] [ 3] fluorinase enzyme,[ 4] fluoroacetate and the antibacterial4-fluoro-L -threonine .[ 5] [ 6] [ 7]
The genome, which was sequenced in 2011, contains one chromosome with 6,283,062 base pairs and one megaplasmid with 1,809,491 bp, with an overall guanine-cytosine content of 73%.[ 8]
^ Bodner, MJ; Li, R; Phelan, RM; Freeman, MF; Moshos, KA; Lloyd, EP; Townsend, CA (Sep 19, 2011)."Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis" .ChemBioChem .12 (14):2159– 65.doi :10.1002/cbic.201100366 .PMC 3281309 PMID 21913298 . ^ Kahan, JS; Kahan, FM; Goegelman, R; Currie, SA; Jackson, M; Stapley, EO; Miller, TW; Miller, AK; Hendlin, D; Mochales, S; Hernandez, S; Woodruff, HB; Birnbaum, J (Jan 1979)."Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties" .The Journal of Antibiotics .32 (1):1– 12.doi :10.7164/antibiotics.32.1 PMID 761989 . ^ Kahan JS, Kahan FM, Goegelman R, et al. (1979)."Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties" .J. Antibiot .32 (1):1– 12.doi :10.7164/antibiotics.32.1 PMID 761989 . ^ O'Hagan, David; Schaffrath, Christoph; Cobb, Steven L.; Hamilton, John T. G.; Murphy, Cormac D. (March 2002)."Biochemistry: Biosynthesis of an organofluorine molecule" .Nature .416 (6878): 279.Bibcode :2002Natur.416..279O .doi :10.1038/416279a PMID 11907567 .S2CID 4415511 . ^ Zhao, C; Li, P; Deng, Z; Ou, HY; McGlinchey, RP; O'Hagan, D (Oct 2012). "Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants".Bioorganic Chemistry .44 :1– 7.doi :10.1016/j.bioorg.2012.06.002 .PMID 22858315 . ^ Reid, KA; Hamilton, JT; Bowden, RD; O'Hagan, D; Dasaradhi, L; Amin, MR; Harper, DB (Jun 1995). "Biosynthesis of fluorinated secondary metabolites by Streptomyces cattleya".Microbiology .141 (6):1385– 93.doi :10.1099/13500872-141-6-1385 .PMID 7670640 . ^ Kuehnel, Karin (May 2019)."A bacterial treasure trove" .Nature Methods (Paper).16 (5): 360.doi :10.1038/s41592-019-0411-1 PMID 31040424 . (subscription required) ^ Barbe, V; Bouzon, M; Mangenot, S; Badet, B; Poulain, J; Segurens, B; Vallenet, D; Marlière, P; Weissenbach, J (Sep 2011)."Complete genome sequence ofStreptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites" .Journal of Bacteriology .193 (18):5055– 6.doi :10.1128/JB.05583-11 .PMC 3165681 PMID 21868806 .
