The first complete genome sequence ofS. avermitilis was completed in 2003.[4] The genome consists of a singlechromosome with a linear structure, unlike most bacterial genomes, which exist in the form of circular chromosomes.[5]
Avermectins are industrially derived from the fermentation products ofS. avermitilis.[1][6] Avermectin itself was discovered by theSatoshi Ōmura group[6] and first disclosed in Burget al. 1979.[1] One of the most widely employed drugs against nematode and arthropod infestations is the avermectin derivativeivermectin, as well asabamectin, a widely used insecticide andantihelmintic.
^Kim, S. B.; Goodfellow, M. (2002). "Streptomyces avermitilis sp. nov., nom. Rev., a taxonomic home for the avermectin-producing streptomycetes".International Journal of Systematic and Evolutionary Microbiology.52 (Pt 6):2011–2014.doi:10.1099/ijs.0.02265-0.PMID12508861.
^Takahashi, Y.; Matsumoto, A.; Seino, A.; Ueno, J.; Iwai, Y.; Omura, S. (2002). "Streptomyces avermectinius sp. nov., an avermectin-producing strain".International Journal of Systematic and Evolutionary Microbiology.52 (Pt 6):2163–2168.doi:10.1099/ijs.0.02237-0.PMID12508884.
