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Staphylococcus aureus beta toxin

From Wikipedia, the free encyclopedia
Toxin produced by Staphylococcus aureus

Staphylococcus aureus beta toxin is a toxin produced byStaphylococcus aureus.[1] It is a form ofsphingomyelinase[2] called sphingomyelinase C. This enzyme is toxic to a variety of cells, includingerythrocytes,fibroblasts,leukocytes, andmacrophages. Susceptible cells are subject tolysis of exposedsphingomyelin on their membrane surfaces.[3]

The beta toxin exhibits maximum activity at 10 °C, at 37 °C (normal body temperature) seems to be inactive.[citation needed]

References

[edit]
  1. ^Cifrian E, Guidry AJ, Bramley AJ, Norcross NL, Bastida-Corcuera FD, Marquardt WW (February 1996)."Effect of staphylococcal β toxin on the cytotoxicity, proliferation and adherence ofStaphylococcus aureus to bovine mammary epithelial cells".Veterinary Microbiology.48 (3–4):187–98.doi:10.1016/0378-1135(95)00159-X.PMID 9054116.
  2. ^Gaskin DK, Bohach GA, Schlievert PM, Hovde CJ (February 1997). "Purification ofStaphylococcus aureus β-toxin: comparison of three isoelectric focusing methods".Protein Expression and Purification.9 (1):76–82.doi:10.1006/prep.1996.0664.PMID 9116505.
  3. ^Patrick R. Murray; Ken S. Rosenthal; Michael A. Pfaller (2009) [1990].Medical Microbiology (6th ed.). Philadelphia: Mosby. p. 213.ISBN 978-0-323-05470-6.
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