Incellular biology, the termsomatic is derived from the French somatique which comes from Ancient Greek σωματικός (sōmatikós, “bodily”), and σῶμα (sôma, “body”.)[1][2] is often used to refer to thecells of the body, in contrast to the reproductive (germline) cells, which usually give rise to theegg orsperm (or othergametes in other organisms). Thesesomatic cells arediploid, containing two copies of eachchromosome, whereas germ cells arehaploid, as they only contain one copy of each chromosome (in preparation forfertilisation). Although under normal circumstances all somatic cells in an organism contain identicalDNA, they develop a variety of tissue-specific characteristics. This process is calleddifferentiation, throughepigenetic and regulatory alterations. The grouping of similar cells and tissues creates the foundation for organs.
Somatic mutations are changes to the genetics of a multicellular organism that are not passed on to its offspring through the germline. Mostcancers are due to somatic mutations.
Somatic is also defined as relating to the wall of the body cavity, particularly as distinguished from the head, limbs, orviscera. It is also used in the termsomatic nervous system, which is the portion of thevertebratenervous system that regulates voluntary movements of the body.
The frequency ofmutations in mouse somatic tissue (brain,liver,Sertoli cells) was compared to the mutation frequency in malegermline cells at sequential stages ofspermatogenesis.[3] The spontaneous mutation frequency was found to be significantly higher (5 to 10-fold) in the somatic cell types than in the male germline cells.[3] In female mice, somatic cells were also found to have a higher mutation frequency than germline cells.[4] It was suggested that elevated levels ofDNA repair enzymes play a prominent role in the lower mutation frequency of male and female germline cells, and that enhanced genetic integrity is a fundamental characteristic of germline cells.[4] DNA repair processes can remove DNA damages that would, otherwise, upon DNA replication, cause mutation.
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