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Sofpironium bromide

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Sofpironium bromide
Clinical data
Trade namesEcclock, Sofdra, others
Other namesBBI-4000, BBI 4000
AHFS/Drugs.comMonograph
MedlinePlusa624052
License data
Routes of
administration
Topical
Drug classAnticholinergic
ATC code
  • None
Legal status
Legal status
Identifiers
  • [(3R)-1-(2-Ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate bromide
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC22H32BrNO5
Molar mass470.404 g·mol−1
3D model (JSmol)
  • CCOC(=O)C[N+]1(CC[C@H](C1)OC(=O)[C@@](C2CCCC2)(C3=CC=CC=C3)O)C.[Br-]
  • InChI=1S/C22H32NO5.BrH/c1-3-27-20(24)16-23(2)14-13-19(15-23)28-21(25)22(26,18-11-7-8-12-18)17-9-5-4-6-10-17;/h4-6,9-10,18-19,26H,3,7-8,11-16H2,1-2H3;1H/q+1;/p-1/t19-,22+,23?;/m1./s1
  • Key:FIAFMTCUJCWADZ-JOFREBOKSA-M

Sofpironium bromide, sold under the brand namesEcclock andSofdra among others, is amedication used to treathyperhidrosis (excessive sweating).[1] Sofpironium bromide is ananticholinergic agent that is applied to the skin.[1]

It was approved for medical use in Japan in 2020,[2] and in the United States in June 2024.[1][3][4][5]

Medical uses

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Sofpironium bromide isindicated for the treatment of primary axillary hyperhidrosis.[1]

Mechanism of action

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The pharmacodynamics of sofpironium bromide are unknown.[1]

Society and culture

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Legal status

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It was approved for medical use in Japan in November 2020,[6] and in the United States in June 2024.[1][7]

Brand names

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Sofpironium bromide is theinternational nonproprietary name.[8]

It is sold under the brand name Ecclock in Japan and under the brand name Sofdra in the US.

References

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  1. ^abcdefg"Sofdra- sofpironium bromide gel".DailyMed. 26 August 2024. Retrieved2 September 2024.
  2. ^Paik J (December 2020). "Sofpironium Bromide: First Approval".Drugs.80 (18):1981–1986.doi:10.1007/s40265-020-01438-1.PMID 33236266.S2CID 227155835.
  3. ^"Drug Approval Package: Sofdra".U.S.Food and Drug Administration (FDA). 17 July 2024. Retrieved2 September 2024.
  4. ^New Drug Therapy Approvals 2024(PDF).U.S.Food and Drug Administration (FDA) (Report). January 2025.Archived from the original on 21 January 2025. Retrieved21 January 2025.
  5. ^"FDA Approves Sofdra topical gel" (Press release).Botanix Pharmaceuticals. 20 June 2024.Archived from the original on 20 June 2024. Retrieved20 June 2024.
  6. ^"Brickell Biotech Announces Launch Date for Sofpironium Bromide Gel, 5% (Ecclock) in Japan by its Development Partner, Kaken Pharmaceutical" (Press release). Brickell Biotech. 18 November 2020. Retrieved2 September 2024 – via GlobeNewswire.
  7. ^"Novel Drug Approvals for 2024".U.S.Food and Drug Administration (FDA). 1 October 2024. Retrieved29 November 2024.
  8. ^World Health Organization (2017). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 77".WHO Drug Information.31 (1).hdl:10665/330984.

Further reading

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External links

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