Sobrietol is a North Americanbrand ofnutritional supplement marketed as a remedy forhangovers and to prevent symptoms associated withalcohol flush reaction. The list of ingredients includes theenzymes quinoproteinalcohol dehydrogenase (QADH) and quinoproteinaldehyde dehydrogenase (QALDH) fromGlucanobacter suboxydans orAcetobacter suboxydans oroxydans, either in purified form or as cell extracts, together with buffering agents and protectants designed to ensure that the enzymes remain biologically active after oral ingestion, and "a source of oxygen in an amount sufficient for the enzymes to metabolize ethanol after administration to a patient."[1]
A 2008 controlled study of breathalcohol levels indicated significantly greater ethanol elimination in subjects given sobrietol vs. placebo.[2] Sobrietol has also been covered by a number of television news programs.[3][4][5][6] Sobrietol has not been evaluated for safety or efficacy by any regulatory agency, such as theU.S. Food and Drug Administration, or theEuropean Medicines Agency.
