| Skraup reaction | |
|---|---|
| Named after | Zdenko Hans Skraup |
| Reaction type | Ring forming reaction |
| Identifiers | |
| RSC ontology ID | RXNO:0000062 |
TheSkraup synthesis is achemical reaction used to synthesizequinolines. It is named after the Czech chemistZdenko Hans Skraup (1850–1910). In the archetypal Skraup reaction,aniline is heated withsulfuric acid,glycerol, and anoxidizing agent such asnitrobenzene to yield quinoline.[1][2][3][4]
In this example,nitrobenzene serves as both thesolvent and the oxidizing agent. The reaction, which otherwise has a reputation for being violent, is typically conducted in the presence offerrous sulfate.[5]Arsenic acid may be used instead of nitrobenzene and the former is better since the reaction is less violent.[6]
{{cite journal}}: CS1 maint: multiple names: authors list (link);Collected Volumes, vol. 1, p. 478.