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| Other names | Cocculine |
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| ECHA InfoCard | 100.003.722 |
| Chemical and physical data | |
| Formula | C19H23NO4 |
| Molar mass | 329.396 g·mol−1 |
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Sinomenine orcocculine is analkaloid found in the root of the climbing plantSinomenium acutum which is native to Japan and China. The plant is traditionally used inherbal medicine in these countries forrheumatism andarthritis.[1] However, analgesic action against other types of pain seems to be limited. Sinomenine is amorphinan derivative that is related to the common cough suppressantdextromethorphan. The drug's anti-rheumatic effects are thought to be primarily mediated via release ofhistamine,[2] but other effects such as inhibition ofprostaglandin,leukotriene andnitric oxide synthesis may also be involved.[3]
