Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Sigma-Aldrich

From Wikipedia, the free encyclopedia
Chemical, life science and biotechnology company
icon
This articlerelies excessively onreferences toprimary sources. Please improve this article by addingsecondary or tertiary sources.
Find sources: "Sigma-Aldrich" – news ·newspapers ·books ·scholar ·JSTOR
(September 2013) (Learn how and when to remove this message)
Merck / MilliporeSigma
Merck logo
The company's logo, designed in 2015[1]
Company typeSubsidiary ofMerck KGaA
Nasdaq: SIAL
Industrychemistry and biotechnology
FoundedAugust 1975
HeadquartersBurlington, Massachusetts,United States[2]
Key people
Jean-Charles Wirth(Life Science CEO)
Productslife science technologies and specialty chemicals
RevenueEUR€ 6.86 billion (2020)[3]
Number of employees
more than 20,000
ParentMerck KGaA (100%)[4]
Websitewww.sigmaaldrich.com

Sigma-Aldrich (part ofMilliporeSigma)[5][6] is a brand operating within an American chemical,life science, andbiotechnology company owned by the multinational chemical conglomerateMerck Group. The life sciences business of Merck Group operates asMilliporeSigma in the United States.[7]

Sigma-Aldrich was created in 1975 by themerger of Sigma Chemical Company and Aldrich Chemical Company. It grew through various acquisitions until it had over 9,600 employees and was listed on theFortune 1000. The company has two United States headquarters, inSt. Louis andBurlington, MA and has operations in approximately 40 countries.[8]

In 2015, the multinational chemical conglomerate Merck Group acquired Sigma-Aldrich for $17 billion.[9] The company is currently a part of Merck's life science business and in combination with Merck's earlier acquiredMillipore, operates asMilliporeSigma.[5][6] It is headquartered in Burlington, Massachusetts, United States.[2]

History

[edit]

Sigma Chemical Company ofSt. Louis and Aldrich Chemical Company ofMilwaukee were both American specialty chemical companies when they merged in August 1975. The company grew throughout the 1980s and 1990s, with significant expansion in facilities, acquisitions and diversification into new market sectors.[citation needed]

Early history

[edit]
  • 1935 – Midwest Consultants was founded inSt Louis by brothers Aaron Fischer and Bernard Fischlowitz, who hired chemical engineer Daniel Broida.[10]
    • 1946 – Sigma was formed from Midwest Consultants and manufactured justadenosine triphosphate. They were the first to manufacture pure ATP.[11]
    • 1972 – Sigma's IPO[12]
  • 1951 – Aldrich founded inMilwaukee byAlfred Bader and Jack Eisendrath and manufactured just1-methyl-3-nitro-1-nitrosoguanidine.
    • 1966 – Aldrich's IPO[13]
    • 1972 – Subsidiary Aldrich-Boranes launched to manufacture hydroboration products
  • 1975 – Merger of Sigma Chemical and Aldrich Chemical to created Sigma-Aldrich.[14] Their first year earned $43 million in sales.[15]
  • 1999 – Sigma-Aldrich reaches $1 billion in sales
  • 2005 – Announced membership inThe RNAi Consortium[16]
  • 2014 –Merck KGaA announced that it would purchase Sigma-Aldrich for approx. $17 billion (€13.1 billion).[17][18]
  • November 3, 2014 – Sigma-Aldrich filed a definitive proxy statement with the U.S.Securities and Exchange Commission to hold a special investors meeting regarding approval for the sale to Merck KGaA.[19]

Acquisitions

[edit]

1970s

[edit]
  • 1978 – Makor Chemicals

1980s

[edit]
  • 1984 – Pathfinder
  • 1986 – Bio Yeda, Bristol Organics
  • 1989 – Fluka Chemie AG (Swiss company founded in the 1950s) purchased for $39 million.

1990s

[edit]
  • 1993 – Supelco, Inc. acquired to enter the chromatography market
  • 1994 – LabKemi AB
  • 1997 – Research Biochemicals International, Riedel-de-Haen, Techcares Systems, Carbolabs, YA Kemia
  • 1998 – Genosys

2000s

[edit]
  • 2000 – First Medical Inc., Amelung GmbH, ARK Scientific
  • 2001 – ISOTEC (produces stable isotopes used in basic research and medical diagnostics)[20]
  • 2004 – Ultrafine (a supplier of contract manufacturing services for drug development), Tetrionics (a producer of high potency and cytotoxic active pharmaceutical ingredients)[21]
  • 2005 – JRH Biosciences,[22] an industrial supplier of cell culture products for the pharmaceutical and biotechnology industries; Proligo Group, a global supplier of genomics research tools
  • 2006 – Beijing Superior Chemicals,[23] Iropharm, Pharmorphix,[24] Advanced Separation Technologies[25] (manufacturer of products forchiral chromatography)
  • 2007 – Epichem[26] acquired to expand capabilities in materials sciences and semiconductor markets; Molecular Medicine BioServices acquired to provide large-scale viral manufacturing capabilities; announced alliance with Sangamo BioSciences to develop zinc finger-based laboratory research reagents
  • 2009 – ChemNavigator
  • 2010 – Cerilliant Corporation, ACE Animals
  • 2011 – Resource Technology Corp, Vetec Quimica Fina
  • 2012 – Research Organics Inc., BioReliance (a toxicology and veterinary diagnostics company);[27] BioReliance had previously been acquired byInvitrogen and subsequently sold toAvista Capital Partners.[28]
  • 2014 – Cell Marque[29]
  • 2015 – Combined with EMD Millipore to make MilliporeSigma.[30]

Key numbers

[edit]

Key numbers for Sigma-Aldrich.[31]

Revenues:[32]

  • $2.79 billion (2014)

Products:

  • 100,000 chemical products (46,000 manufactured)
  • 30,000 laboratory equipment products

Customers:

  • Approximately one million individual customers worldwide
  • 88,000 accounts

Geographies (% of 2008 sales):

  • United States 35%
  • Europe 43%
  • Canada, Asia Pacific, Latin America 22%

Subsidiaries

[edit]
icon
This sectiondoes notcite anysources. Please helpimprove this section byadding citations to reliable sources. Unsourced material may be challenged andremoved.(November 2014) (Learn how and when to remove this message)
The Aldrich Logo.

Aldrich is a supplier in the research andfine chemicals market. Aldrich providesorganic andinorganic chemicals, building blocks,reagents, advanced materials and stableisotopes forchemical synthesis, medicinalchemistry andmaterials science. Aldrich's chemicals catalog, the "Aldrich Catalog and Handbook" is often used as ahandbook due to the inclusion ofstructures,physical data, and literaturereferences.

The Sigma Logo.

Sigma is the Sigma-Aldrich's main biochemical supplier, with offerings includingantibiotics,buffers,carbohydrates,enzymes,forensic tools,hematology andhistology,nucleotides,proteins,peptides,amino acids and their derivatives.

The Sigma RBI Logo.

Sigma RBI produces specialized products for use in the field ofcell signaling andneuroscience. Their offerings range from standard biochemical reagents to specialized research tools, includingligands forreceptors andion channels,enzyme inhibitors, phosphospecificantibodies, key signal transduction enzymes, andassay kits for cell signaling.

The ISOTEC Logo.

ISOTEC providesisotopically labeled products forprotein structure determination,peptide synthesis,proteomics,metabolic research,magnetic resonance imaging,nuclear magnetic resonance,breath testsubstrates,agriculture, as well asgas and gas mixes.

The Riedel-de Haën Logo.

Riedel-de Haën was incorporated with Sigma-Aldrich in 1999 and manufactures reagents and standards.

The Supelco Logo.

Supelco is thechromatography products branch of Sigma-Aldrich. It provideschromatography columns and related tools forenvironmental,government, food and beverage,pharmaceutical,biotechnology,medical andchemical laboratories; sample preparation products and chemical reference standards.

The SAFC Logo.

Sigma-Aldrich Fine Chemicals (SAFC) is the fine chemical supply branch of Sigma-Aldrich specializing in raw materials forcell culture products; customized services for raw materials, manufacturing of activepharmaceutical ingredients.

Sigma Life Science provides products such as customDNA/RNAoligos; custom DNA andLNA probes;siRNA; isotopically-labelled peptides and peptide libraries.

Sigma Advanced Genetic Engineering (SAGE) Labs was a division within Sigma-Aldrich that specializes ingenetic manipulation of in vivo systems for special research and development applications. It was formed in 2008 to investigatezinc finger nuclease technology and its application for disease research models. Located in St. Louis, Missouri, SAGE Labs have developedknockout rats for the study of human diseases and disorders (such as autism), which are sold for up to US$95,000. SAGE also announced its first successful effort in creating a "knockout rabbit".[33] Its facilities include a specific pathogen free, biosecurevivarium as well as research and development labs. SAGE Labs was acquired by Horizon Discovery Group in 2014.[34]

Carbolabs produces research quantities of chemicals produced byphosgenation reactions. The company was acquired in 1998.[35]

BioReliance provides testing and manufacturing services to pharmaceutical and biopharmaceutical companies that span the product cycle from early pre-clinical development to licensed production.The company was acquired by Sigma Aldrich in January 2012.

Current leadership

[edit]

Jean-Charles Wirth became CEO of the Life Science business of Merck KGaA, Darmstadt, Germany in June 2025 following Matthias Heinzel's departure from the company.[36]

References

[edit]
  1. ^Vit, Armin (October 15, 2015)."Good Vibrations".Brand New. UnderConsideration.
  2. ^abCarlock, Catherine (January 20, 2021)."MilliporeSigma buys its Burlington HQ for $252M".Boston Business Journal.
  3. ^Annual Report 2020(PDF) (Report). EMD Group, part of Merck KGaA. 2020. Archived fromthe original(PDF) on August 13, 2022.
  4. ^"Merck KGaA, Darmstadt, Germany, Completes Sigma-Aldrich Acquisition"(XBRL). Merck. November 18, 2015.
  5. ^ab"Customer Letter". Archived fromthe original on 2016-02-08. Retrieved2016-01-04.
  6. ^abAbout Us, EMD Millipore + Sigma-Aldrich = MilliporeSigma, The life science business of Merck KGaA, Darmstadt, Germany
  7. ^Marc s. Reisch (2015-11-30)."The Making Of MilliporeSigma".Chemical & Engineering News Archive.93 (47):17–18.doi:10.1021/cen-09347-bus2.ISSN 0009-2347.
  8. ^"Sigma-Aldrich Corporation – Investor Relations".
  9. ^"Sigma-Aldrich, Merck KGaA Press Release"(PDF).news.emdgroup.com.
  10. ^"80 Humble Beginnings for a Great Company".stltoday.com. 3 October 2014.
  11. ^"80 Years Fueling Scientific Discovery".sigmaaldrich.com.
  12. ^"80 Years Fueling Scientific Discovery".sigmaaldrich.com.
  13. ^"80 Years Fueling Scientific Discovery".sigmaaldrich.com.
  14. ^"Funding Universe History of Sigma-Aldrich Corporation".Funding-Universe.
  15. ^"80 Years Fueling Scientific Discovery".sigmaaldrich.com.
  16. ^"Sigma-Aldrich".www.ncbi.nlm.nih.gov.
  17. ^Ludwig Burger (September 22, 2014)."Germany's Merck to buy Sigma-Aldrich for $17 billion to boost lab supplies operation".Reuters. RetrievedSeptember 23, 2014.
  18. ^Staff (October 15, 2014). "Merck KGaA to Acquire Sigma-Aldrich for $17B".Genetic Engineering & Biotechnology News. p. 10.
  19. ^"Sigma-Aldrich Corporation Announces Filing Of Definitive Proxy Statement And Date Of Special Meeting Of Stockholders". Acquire Media. Archived fromthe original on December 28, 2014. Retrieved3 November 2014.
  20. ^"Sigma-Aldrich Corp acquires Isotec Inc from Taiyo Nippon Sanso Corp".
  21. ^"Sigma-Aldrich Corp acquires Ultrafine".
  22. ^"Sigma-Aldrich Corp acquires JRH Biosciences Inc from CSL Ltd - Deal Snapshot - AlacraStore.com".www.alacrastore.com.
  23. ^"Sigma-Aldrich Corp acquires Beijing Superior Chem & Instr - Apr 03, 2006 - M&A Deal Snapshot - AlacraStore.com".www.alacrastore.com.
  24. ^"Sigma-Aldrich Corp acquires Pharmorphix Ltd".
  25. ^"Sigma-Aldrich Corp acquires Advanced Separation Tech Inc from Calgon Carbon Corp".
  26. ^"Sigma-Aldrich Corp acquires Epichem Group Ltd - Feb 12, 2007 - M&A Deal Snapshot - AlacraStore.com".www.alacrastore.com.
  27. ^"Sigma-Aldrich to buy BioReliance Hldgs for $350M",News,Bioscience Technology, Associated Press, 9 Jan 2012, retrieved11 Jan 2012
  28. ^Invitrogen Completes Divestiture of BioReliance (press release),Life Technologies, 12 April 2007, archived fromthe original on 2012-03-30, retrieved11 Jan 2012
  29. ^"80 Years Fueling Scientific Discovery".sigmaaldrich.com.
  30. ^"The Making Of MilliporeSigma".Chemical & Engineering News. Retrieved2025-07-07.
  31. ^"SIGMA ALDRICH CORP (10-K), Consolidated Statements of Income"(XBRL). United States Securities and Exchange Commission. February 12, 2015.
  32. ^"Sigma-Aldrich Corporate Fact Sheet"(PDF).www.sigmaaldrich.com.
  33. ^"SAGE's Latest Knockout: $95,000 Lab Rats".Fast Company.
  34. ^Today, Cap (2014-12-12)."Horizon acquires Sage Labs, 12/14 - CAP TODAY".www.captodayonline.com. Retrieved2025-07-07.
  35. ^"Carbolabs purchased".ICIS.
  36. ^"Merck KGaA to replace two executives with company veterans".Reuters.

External links

[edit]

Media related toSigma-Aldrich at Wikimedia Commons

Subsidiaries
People
Related
International
National
Other
Retrieved from "https://en.wikipedia.org/w/index.php?title=Sigma-Aldrich&oldid=1317283464"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2026 Movatter.jp