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Sifalimumab

From Wikipedia, the free encyclopedia
Human monoclonal antibody
Pharmaceutical compound
Sifalimumab
Fab fragment of sifalimumab bound to IFN-α2A. FromPDB:4ypg​.
Monoclonal antibody
TypeWhole antibody
SourceHuman
TargetInterferon α
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6518H10008N1724O2032S38
Molar mass146252.08 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Sifalimumab is a human monoclonal antibody designed for the treatment ofSLE,dermatomyositis, andpolymyositis.[1] It targets interferon a.[2]

Sifalimumab was developed byMedImmune; as of 2017 development had been terminated in favor of moving a competing internal product,anifrolumab, into Phase III trials.[3][4][5]

References

[edit]
  1. ^Greth W, Robbie GJ, Brohawn P, Hultquist M, Yao B (January 2017). "Targeting the interferon pathway with sifalimumab for the treatment of systemic lupus erythematosus".Immunotherapy.9 (1):57–70.doi:10.2217/imt-2016-0090.PMID 28000522.
  2. ^"Statement On A Nonproprietary Name Adopted By The USAN Council: Sifalimumab"(PDF).American Medical Association.
  3. ^"Press release: New Hope for Lupus Patients". MedImmune. 11 August 2015. Archived fromthe original on 31 July 2017.
  4. ^"Sifalimumab".AdisInsight. Springer Nature Switzerland AG. Retrieved31 July 2017.
  5. ^"Sifalimumab". NHS Specialist Pharmacy Service. Retrieved31 July 2017.
Immune system
Human
Mouse
Chimeric
Humanized
Chimeric + humanized
Interleukin
Human
Humanized
Veterinary
Inflammatorylesions
Mouse
Chemokine
CSF
Erythropoietin
G-CSF (CSF3)
GM-CSF (CSF2)
M-CSF (CSF1)
SCF (c-Kit)
Thrombopoietin
Interferon
IFNAR (α/β, I)
IFNGR (γ, II)
IFNLR (λ, III)
  • See IL-28R (IFNLR)here instead.
Interleukin
TGFβ
TNF
Others
JAK
(inhibitors)
JAK1
JAK2
JAK3
TYK2
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