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| Second-generation antidepressant | |
|---|---|
| Drug class | |
| Class identifiers | |
| Use | Depressive disorders |
| External links | |
| MeSH | D018687 |
| Legal status | |
| In Wikidata | |
Thesecond-generation antidepressants are a class ofantidepressants characterized primarily by the era of their introduction, approximately coinciding with the 1970s and 1980s, rather than by theirchemical structure or by theirpharmacological effect. As a consequence, there is some controversy over which treatments actually belong in this class.
The term "third generation antidepressant" is sometimes used to refer to newer antidepressants,[1] from the 1990s and 2000s, oftenselective serotonin reuptake inhibitors (SSRIs) such as;fluoxetine (Prozac),paroxetine (Paxil) andsertraline (Zoloft), as well as some non-SSRI antidepressants such asmirtazapine,nefazodone,venlafaxine,duloxetine andreboxetine. However, this usage is not universal.
This list is not exhaustive, and different sources vary upon which items should be considered second-generation.
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