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Satratoxin-H

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Satratoxin-H
Names
IUPAC name
(2'R,4E,9R,10E,12Z,16R,16aS,18R,19aR,23aR,25R)-6,7,16,16a,19a,22-

hexahydro-25-hydroxy-9-((1S)-1-hydroxyethyl)-16a,21-dimethyl-spiro(5,9,16,18-dimethano-1H,3H,23H-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyran-17(18H)-2'-oxirane)-

3,14(9H)-dione
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C29H36O9/c1-17-7-10-27-15-34-24(32)13-19-8-11-35-28(18(2)30,25(19)33)9-5-4-6-23(31)38-20-14-22(37-21(27)12-17)29(16-36-29)26(20,27)3/h4-6,9,12-13,18,20-22,25,30,33H,7-8,10-11,14-16H2,1-3H3/b6-4-,9-5+,19-13+/t18-,20+,21+,22+,25+,26+,27+,28+,29+/m0/s1 checkY
    Key: MUACSCLQRGEGOE-PQGPUMQGSA-N checkY
  • InChI=1/C29H36O9/c1-17-7-10-27-15-34-24(32)13-19-8-11-35-28(18(2)30,25(19)33)9-5-4-6-23(31)38-20-14-22(37-21(27)12-17)29(16-36-29)26(20,27)3/h4-6,9,12-13,18,20-22,25,30,33H,7-8,10-11,14-16H2,1-3H3/b6-4-,9-5+,19-13+/t18-,20+,21+,22+,25+,26+,27+,28+,29+/m0/s1
    Key: MUACSCLQRGEGOE-PQGPUMQGBS
  • C[C@H](O)[C@@]12\C=C\C=C/C(=O)O[C@@H]4C[C@H]6O[C@@H]3/C=C(/C)CC[C@]3(COC(=O)/C=C(\CCO1)[C@H]2O)[C@]4(C)[C@]56CO5
Properties
C29H36O9
Molar mass528.591
insoluble
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Highly toxic
GHS labelling:
GHS06: Toxic
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

Satratoxin-H, atrichothecenemycotoxin, is a naturally occurring toxin produced by theascomycetesStachybotrys chartarum andTrichoderma cornu-damae which is highly toxic and potentially fatal to humans and other animals. The clinical condition it causes is known asStachybotrotoxicosis. It is related to the mycotoxinT-2, but unlike T-2 has not been reported to have been used as achemical weapon.

Properties

[edit]

Satratoxin-H is almost completely insoluble in water, but is easily soluble in lower alcohols and polar solvents such asethanol,methanol,2-propanol,acetone andchloroform.[1]

Satratoxin-H is not officially classified as achemical weapon.[citation needed]

Effects

[edit]

Satratoxin-H is extremely versatile. Contact with the solution through ingestion, inhalation, or even prolonged physical contact produces symptoms similar to those listed below.

However, if consumed in large quantities, it can be lethal. Satratoxin-H has little effect on bare skin, and does not blister it in the way many chemical weapons do. However, upon contact with sensitive surfaces (eyes, interior of mouth or nose), inflammation will occur.

Satratoxin-H has anLD50 for mice of 1.0-1.4 mg/kg, upon injection. Otherwise it is reported to be about five times as toxic as T-2.[2]

References

[edit]
  1. ^Satratoxin H:essential dataArchived 2007-05-05 at theWayback Machine
  2. ^A mycotoxin with punch!
Bacterial
toxins
Exotoxin
Gram
positive
Bacilli
Clostridium:
Other:
Cocci
Staphylococcus
Actinomycetota
Gram
negative
Mechanisms
Endotoxin
Virulence
factor
Mycotoxins
Plant toxins
Invertebrate
toxins
Scorpion:
Spider:
Mollusca:
Vertebrate
toxins
Fish:
Amphibian:
Reptile/
Snake venom:
  • note: some toxins are produced by lower species and pass through intermediate species
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