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SYT7

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

SYT7

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2D8K

Identifiers

Aliases

SYT7, IPCA-7, IPCA7, PCANAP7, SYT-VII, SYTVII, synaptotagmin 7

External IDs

OMIM:604146;MGI:1859545;HomoloGene:20889;GeneCards:SYT7;OMA:SYT7 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q12.2	Start	61,513,714bp^[1]
Band	11q12.2	End	61,581,148bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	10,366,454bp^[2]
Band	19\|19 A	End	10,430,544bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

islet of Langerhans

right hemisphere of cerebellum

right frontal lobe

Brodmann area 9

prefrontal cortex

cerebellar vermis

cingulate gyrus

anterior cingulate cortex

right lobe of liver

pituitary gland

Top expressed in

medial dorsal nucleus

medial geniculate nucleus

dentate gyrus

piriform cortex

substantia nigra

primary visual cortex

dentate gyrus of hippocampal formation granule cell

cerebellar cortex

cerebellar vermis

lobe of cerebellum

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	calcium ion binding metal ion binding protein binding SNARE binding syntaxin binding clathrin binding phosphatidylinositol-4,5-bisphosphate binding calcium-dependent phospholipid binding calmodulin binding phosphatidylserine binding
Cellular component	integral component of membrane membrane synapse synaptic vesicle membrane cell junction terminal bouton dense core granule extracellular exosome cytoplasmic vesicle transport vesicle membrane cytosol synaptic vesicle presynaptic membrane lysosome peroxisome peroxisomal membrane phagocytic vesicle membrane plasma membrane lysosomal membrane early phagosome dendrite soma axon terminus axon neuron projection exocytic vesicle hippocampal mossy fiber to CA3 synapse glutamatergic synapse GABA-ergic synapse integral component of presynaptic membrane
Biological process	regulation of insulin secretion positive regulation of calcium ion-dependent exocytosis exocytosis regulation of bone remodeling plasma membrane repair calcium-ion regulated exocytosis regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter regulation of glucagon secretion phagosome-lysosome fusion synaptic vesicle recycling vesicle-mediated cholesterol transport regulation of phagocytosis vesicle fusion calcium ion regulated lysosome exocytosis phagocytosis regulation of dopamine secretion short-term synaptic potentiation vesicle-mediated transport cellular response to calcium ion calcium-dependent activation of synaptic vesicle fusion regulation of synaptic vesicle endocytosis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


9066


54525

Ensembl


ENSG00000011347


ENSMUSG00000024743

UniProt


O43581


Q9R0N7

RefSeq (mRNA)

NM_001252065 NM_001300773 NM_004200 NM_001365809 NM_001370210
NM_001370211


NM_018801 NM_173067 NM_173068 NM_001373944

RefSeq (protein)

NP_001238994 NP_001287702 NP_004191 NP_001352738 NP_001357139
NP_001357140


NP_061271 NP_775090 NP_775091

Location (UCSC)

Chr 11: 61.51 – 61.58 Mb

Chr 19: 10.37 – 10.43 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Synaptotagmin-7 is aprotein that in humans is encoded by theSYT7gene.^[5]^[6]

Function

[edit]

Synaptotagmins, such as SYT7, are calcium-dependent phospholipid-binding proteins known for their role in synaptic exocytosis and neurotransmitter release. Significant expression has also been observed in the prostate and other tissues. See MIM 600782 [supplied by OMIM]^[6]

Interactions

[edit]

SYT7 has been shown tointeract withSYNCRIP.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000011347 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000024743 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB (May 1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes".Genomics.49 (3):419–29.doi:10.1006/geno.1998.5291.PMID 9615227.
^^a ^b"Entrez Gene: SYT7 synaptotagmin VII".
^Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000)."SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms".The Journal of Biological Chemistry.275 (13):9823–31.doi:10.1074/jbc.275.13.9823.PMID 10734137.

External links

[edit]

Overview of all the structural information available in thePDB forUniProt:O43581 (Human Synaptotagmin-7) at thePDBe-KB.
Overview of all the structural information available in thePDB forUniProt:Q9R0N7 (Mouse Synaptotagmin-7) at thePDBe-KB.

v t e PDB gallery
2d8k: Solution structure of the first C2 domain of synaptotagmin VII

Membrane protein:vesicular transport proteins (TC 1F)

Synaptic vesicle

SNARE

Q-SNARE	SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc-18:STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6
R-SNARE	Synaptobrevin/VAMP:VAMP1 VAMP2 VAMP3

Synaptotagmin

Other

Small GTPase:RAB3A

COPI

Coatomer

Small GTPase:ARF

COPII

Coatomer
- SEC23A/SEC24A
- SEC13/SEC31

Small GTPase:SAR1A

RME/Clathrin

Caveolae

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:	AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3
Adaptor protein complex 2:	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1
Adaptor protein complex 3:	AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2
Adaptor protein complex 4:	AP4B1 AP4E1 AP4M1 AP4S1
LMAN1
LYST
BLOC-1:	DTNBP1 BLOC153
BLOC-2:	HPS3 HPS5 HPS6
BLOC-3:	HPS1 HPS4
Coats:	Retromer TIP47