| Sad1_UNC | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Sad1_UNC | ||||||||
| Pfam | PF07738 | ||||||||
| Pfam clan | CL0202 | ||||||||
| InterPro | IPR012919 | ||||||||
| |||||||||
SUN (Sad1p, UNC-84)domains are conserved C-terminalprotein regions a few hundredamino acids long. SUN domains are usually found following a transmembrane domain and a less conserved region of amino acids. Most proteins containing SUN domains are thought to be involved in the positioning of thenucleus in the cell. It is thought that SUN domains interact directly withKASH domains in the space between the outer and inner nuclear membranes to bridge thenuclear envelope and transfer force from the nucleoskeleton to the cytoplasmiccytoskeleton which enables mechanosensory roles in cells.[1] SUN proteins are thought to localize to the inner nuclear membrane.[2] TheS. pombe Sad1 protein localises at thespindle pole body. In mammals, the SUN domain is present in two proteins,Sun1 andSun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.[3][4]
Mammals
Maize
Arabidopsis