Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

SR-144,528

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
SR-144,528
Clinical data
ATC code
  • none
Identifiers
  • 5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
ChEBI
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC29H34ClN3O
Molar mass476.06 g·mol−1
3D model (JSmol)
  • CC1=CC=C(C=C1)CN2C(=CC(=N2)C(=O)N[C@H]3[C@]4(CC[C@H](C4)C3(C)C)C)C5=CC(=C(C=C5)Cl)C
  • InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1 ☒N
  • Key:SUGVYNSRNKFXQM-XRHWURSXSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

SR144528 is a drug that acts as a potent and highly selectiveCB2receptorinverse agonist, with aKi of 0.6 nM at CB2 and 400 nM at the related CB1 receptor.[1][2] It is used in scientific research for investigating the function of the CB2 receptor,[3][4][5][6] as well as for studying the effects of CB1 receptors in isolation, as few CB1 agonists that do not also show significant activity as CB2 agonists are available.[7][8][9] It has also been found to be an inhibitor ofsterol O-acyltransferase, an effect that appears to be independent from its action on CB2 receptors.[10]

See also

[edit]

References

[edit]
  1. ^Rinaldi-Carmona M, Barth F, Millan J, Derocq JM, Casellas P, Congy C, et al. (February 1998)."SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor".The Journal of Pharmacology and Experimental Therapeutics.284 (2):644–50.PMID 9454810.
  2. ^Portier M, Rinaldi-Carmona M, Pecceu F, Combes T, Poinot-Chazel C, Calandra B, et al. (February 1999)."SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist".The Journal of Pharmacology and Experimental Therapeutics.288 (2):582–9.PMID 9918562.
  3. ^Gouldson P, Calandra B, Legoux P, Kernéis A, Rinaldi-Carmona M, Barth F, et al. (July 2000). "Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB(2) receptor".European Journal of Pharmacology.401 (1):17–25.doi:10.1016/S0014-2999(00)00439-8.PMID 10915832.
  4. ^Nackley AG,Makriyannis A, Hohmann AG (4 July 2003). "Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation".Neuroscience.119 (3):747–57.doi:10.1016/S0306-4522(03)00126-X.PMID 12809695.S2CID 6447695.
  5. ^Páldy E, Bereczki E, Sántha M, Wenger T, Borsodi A, Zimmer A, Benyhe S (December 2008). "CB(2) cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB(2) receptor in pain".Neurochemistry International.53 (6–8):309–16.doi:10.1016/j.neuint.2008.08.005.PMID 18804501.S2CID 22671432.
  6. ^Saroz Y, Kho DT, Glass M, Graham ES, Grimsey NL (2019-10-19)."Cannabinoid Receptor 2 (CB 2 ) Signals via G-alpha-s and Induces IL-6 and IL-10 Cytokine Secretion in Human Primary Leukocytes".ACS Pharmacology & Translational Science.2 (6):414–428.doi:10.1021/acsptsci.9b00049.ISSN 2575-9108.PMC 7088898.PMID 32259074.
  7. ^Lay L, Angus JA, Wright CE (March 2000). "Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse".European Journal of Pharmacology.391 (1–2):151–61.doi:10.1016/S0014-2999(00)00062-5.PMID 10720647.
  8. ^Germanò MP, D'Angelo V, Mondello MR, Pergolizzi S, Capasso F, Capasso R, et al. (February 2001). "Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats".Naunyn-Schmiedeberg's Archives of Pharmacology.363 (2):241–4.doi:10.1007/s002100000360.PMID 11218077.S2CID 2655432.
  9. ^Abalo R, Cabezos PA, Vera G, Fernández-Pujol R, Martín MI (June 2010). "The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212-2 on gastrointestinal motility in the rat".Neurogastroenterology and Motility.22 (6): 694–e206.doi:10.1111/j.1365-2982.2009.01466.x.PMID 20132133.S2CID 10520671.
  10. ^Thewke D, Freeman-Anderson N, Pickle T, Netherland C, Chilton C (April 2009)."AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors".Biochemical and Biophysical Research Communications.381 (2):181–6.doi:10.1016/j.bbrc.2009.02.020.PMC 2665256.PMID 19338772.
Phytocannabinoids
(comparison)
Cannabibutols
Cannabichromenes
Cannabicyclols
Cannabidiols
Cannabielsoins
Cannabigerols
Cannabiphorols
Cannabinols
Cannabitriols
Cannabivarins
Delta-3-tetrahydrocannabinols
Delta-4-tetrahydrocannabinols
Delta-7-tetrahydrocannabinols
Delta-8-tetrahydrocannabinols
Delta-9-tetrahydrocannabinols
Delta-10-Tetrahydrocannabinols
Delta-11-Tetrahydrocannabinols
Miscellaneous cannabinoids
Active metabolites
Endocannabinoids
Synthetic
cannabinoid
receptor
agonists /
neocannabinoids
Classical cannabinoids
(dibenzopyrans)
Non-classical
cannabinoids
Adamantoylindoles
Benzimidazoles
Benzoylindoles
Cyclohexylphenols
Eicosanoids
Indazole-3-
carboxamides
Indole-3-carboxamides
Indole-3-carboxylates
Naphthoylindazoles
Naphthoylindoles
Naphthoylpyrroles
Naphthylmethylindenes
Naphthylmethylindoles
Phenylacetylindoles
Pyrazolecarboxamides
Tetramethylcyclo-
propanoylindazoles
Tetramethylcyclo-
propanoylindoles
Others
AllostericCBRTooltip Cannabinoid receptorligands
Endocannabinoid
enhancers
(inactivation inhibitors)
Anticannabinoids
(antagonists/inverse
agonists/antibodies)
Receptor
(ligands)
CB1Tooltip Cannabinoid receptor type 1
Agonists
(abridged,
full list)
Inverse agonists
Antagonists
CB2Tooltip Cannabinoid receptor type 2
Agonists
Antagonists
NAGly
(GPR18)
Agonists
Antagonists
GPR55
Agonists
Antagonists
GPR119
Agonists
Transporter
(modulators)
eCBTsTooltip Endocannabinoid transporter
Enzyme
(modulators)
FAAHTooltip Fatty acid amide hydrolase
MAGL
ABHD6
ABHD12
Others
  • Others:2-PG(directly potentiates activity of 2-AG at CB1 receptor)
  • ARN-272(FAAH-like anandamide transporter inhibitor)
See also
Receptor/signaling modulators
Cannabinoids (cannabinoids by structure)
Stub icon

Thiscannabinoid related article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=SR-144,528&oldid=1268765928"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp