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SPIB

From Wikipedia, the free encyclopedia
Protein that controls transcription of a set of genes in eukaryotes
SPIB
Identifiers
AliasesSPIB, SPI-B, Spi-B transcription factor
External IDsOMIM:606802;MGI:892986;HomoloGene:79220;GeneCards:SPIB;OMA:SPIB - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SPIB
Genomic location for SPIB
Band19q13.33Start50,418,938bp[1]
End50,431,314bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SPIB
Genomic location for SPIB
Band7 B3|7 28.83 cMStart44,175,417bp[2]
End44,181,495bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lymph node

  • mucosa of transverse colon

  • appendix

  • granulocyte

  • buccal mucosa cell

  • spleen

  • rectum

  • mucosa of ileum

  • epithelium of nasopharynx

  • blood
Top expressed in
  • mesenteric lymph nodes

  • spleen

  • tibiofemoral joint

  • blood

  • granulocyte

  • subcutaneous adipose tissue

  • submandibular gland

  • bone marrow

  • thymus

  • femur
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6689

272382

Ensembl

ENSG00000269404

ENSMUSG00000008193

UniProt

Q01892

O35906

RefSeq (mRNA)

NM_003121
NM_001243998
NM_001243999
NM_001244000

NM_019866

RefSeq (protein)

NP_001230927
NP_001230928
NP_001230929
NP_003112

NP_063919

Location (UCSC)Chr 19: 50.42 – 50.43 MbChr 7: 44.18 – 44.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor Spi-B is aprotein that in humans is encoded by theSPIBgene.[5][6]

Function

[edit]

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM][6]

Interactions

[edit]

SPIB has been shown tointeract withMAPK3[7] andMAPK8.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000269404Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000008193Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992)."Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1".Molecular and Cellular Biology.12 (10):4297–304.doi:10.1128/mcb.12.10.4297.PMC 360353.PMID 1406622.
  6. ^ab"Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)".
  7. ^abMao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors".Oncogene.12 (4):863–73.PMID 8632909.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous
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