This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.[6]
In melanocytic cells SOX13 gene expression may be regulated byMITF.[7]
Wilson M, Koopman P (Aug 2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators".Current Opinion in Genetics & Development.12 (4):441–6.doi:10.1016/S0959-437X(02)00323-4.PMID12100890.
Argentaro A, Olsson J, Critcher R, McDowall SG, Harley VR (May 2000). "Genomic characterisation and fine mapping of the human SOX13 gene".Gene.250 (1–2):181–9.doi:10.1016/S0378-1119(00)00157-8.PMID10854791.
Kasimiotis H, Fida S, Rowley MJ, Mackay IR, Zimmet PZ, Gleason S, Rabin DU, Myers MA (2001). "Antibodies to SOX13 (ICA12) are associated with type 1 diabetes".Autoimmunity.33 (2):95–101.doi:10.3109/08916930108995994.PMID11264788.S2CID43867785.
Argentaro A, Wapelhorst B, Concannon P, Harley VR (Apr 2001). "Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes".Molecular Genetics and Metabolism.72 (4):356–9.doi:10.1006/mgme.2000.3136.PMID11286511.
Fida S, Myers M, Mackay IR, Zimmet PZ, Mohan V, Deepa R, Rowley MJ (Jun 2001). "Antibodies to diabetes-associated autoantigens in Indian patients with Type 1 diabetes: prevalence of anti-ICA512/IA2 and anti-SOX13".Diabetes Research and Clinical Practice.52 (3):205–11.doi:10.1016/S0168-8227(01)00230-3.PMID11323090.
Fida S, Myers MA, Whittingham S, Rowley MJ, Ozaki S, Mackay IR (Dec 2002). "Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases".Journal of Autoimmunity.19 (4):251–7.doi:10.1006/jaut.2002.0622.PMID12473246.
