Movatterモバイル変換

[0]ホーム

Jump to content

SOCS6

Edit links

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

SOCS6

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2VIF

Identifiers

Aliases

SOCS6, CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4, suppressor of cytokine signaling 6

External IDs

OMIM:605118;MGI:1924885;HomoloGene:3120;GeneCards:SOCS6;OMA:SOCS6 - orthologs

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18q22.2	Start	70,289,045bp^[1]
Band	18q22.2	End	70,330,199bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 E4	Start	88,683,348bp^[2]
Band	18\|18 E4	End	88,945,605bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of paranasal sinus

biceps brachii

Skeletal muscle tissue of rectus abdominis

jejunal mucosa

oral cavity

mucosa of colon

mucosa of sigmoid colon

Skeletal muscle tissue of biceps brachii

right ventricle

caput epididymis

Top expressed in

otic vesicle

otic placode

zygote

saccule

secondary oocyte

pineal gland

yolk sac

intercostal muscle

soleus muscle

medial geniculate nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein kinase inhibitor activity protein binding 1-phosphatidylinositol-3-kinase regulator activity
Cellular component	cytoplasm immunological synapse cytosol phosphatidylinositol 3-kinase complex
Biological process	regulation of growth defense response proteasomal protein catabolic process receptor signaling pathway via JAK-STAT negative regulation of signal transduction intracellular signal transduction negative regulation of T cell activation protein ubiquitination negative regulation of protein kinase activity cytokine-mediated signaling pathway negative regulation of receptor signaling pathway via JAK-STAT post-translational protein modification regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphate biosynthetic process
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


9306


54607

Ensembl


ENSG00000170677


ENSMUSG00000056153

UniProt


O14544


Q9JLY0

RefSeq (mRNA)


NM_004232 NM_016387


NM_018821

RefSeq (protein)


NP_004223


NP_061291

Location (UCSC)

Chr 18: 70.29 – 70.33 Mb

Chr 18: 88.68 – 88.95 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Suppressor of cytokine signaling 6 is aprotein that in humans is encoded by theSOCS6gene.^[5]^[6]^[7]

The protein encoded by this gene contains aSH2 domain and a CIS homolog domain. The protein thus belongs to thecytokine-induced STAT inhibitor (CIS), also known assuppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI)protein family. CIS family members are known to be cytokine-induciblenegative regulators of cytokine signaling. The expression of this gene can be induced byGM-CSF andEPO inhematopoietic cells. A high expression level of this gene was found in factor-independentchronic myelogenous leukemia (CML) anderythroleukemia (HEL)cell lines.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000170677 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000056153 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Nov 1997). "Cloning and characterization of novel CIS family genes".Biochem Biophys Res Commun.239 (2):439–46.doi:10.1006/bbrc.1997.7484.PMID 9344848.
^Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000)."Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells".Genome Res.10 (10):1546–60.doi:10.1101/gr.140200.PMC 310934.PMID 11042152.
^^a ^b"Entrez Gene: SOCS6 suppressor of cytokine signaling 6".

Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation".Trends Biochem. Sci.27 (5):235–41.doi:10.1016/S0968-0004(02)02085-6.PMID 12076535.
Mooney RA, Senn J, Cameron S, et al. (2001)."Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance".J. Biol. Chem.276 (28):25889–93.doi:10.1074/jbc.M010579200.PMID 11342531.
Krebs DL, Uren RT, Metcalf D, et al. (2002)."SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation".Mol. Cell. Biol.22 (13):4567–78.doi:10.1128/MCB.22.13.4567-4578.2002.PMC 133908.PMID 12052866.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Bayle J, Letard S, Frank R, et al. (2004)."Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling".J. Biol. Chem.279 (13):12249–59.doi:10.1074/jbc.M313381200.PMID 14707129.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells".Science.307 (5715):1621–5.Bibcode:2005Sci...307.1621B.doi:10.1126/science.1105776.PMID 15761153.S2CID 39457788.
Bayle J, Lopez S, Iwaï K, et al. (2006)."The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins".FEBS Lett.580 (11):2609–14.doi:10.1016/j.febslet.2006.03.093.PMID 16643902.S2CID 44648698.
Hwang MN, Ha TH, Park J, et al. (2007). "Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation".Biochem. Biophys. Res. Commun.354 (1):184–9.doi:10.1016/j.bbrc.2006.12.175.PMID 17210122.
Hwang MN, Min CH, Kim HS, et al. (2007). "The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels".Biochem. Biophys. Res. Commun.360 (2):333–8.doi:10.1016/j.bbrc.2007.06.062.PMID 17603019.

JAK-STAT signaling pathway

Ligand

Cytokine

Cytokine receptor

Janus kinase

Adaptor proteins

STAT	STAT1 STAT2 STAT3 STAT4 STAT5 STAT6
PIAS	PIAS1 PIAS2 PIAS3 PIAS4
SOCS	1 2 3 4 5 6 7 CISH
IRF	IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8

This article on agene on humanchromosome 18 is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=SOCS6&oldid=1142789478"

Categories:

Hidden categories:

[8]ページ先頭

Movatterモバイル変換

References

Further reading