Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known asorganic anion-transporting polypeptide 1B3 (OATP1B3) is aprotein that in humans is encoded by theSLCO1B3gene.[5]
OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from theportal vein.
OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.[6] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.[7]
In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.[7]
Vavricka SR, Jung D, Fried M, et al. (2004). "The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma".J. Hepatol.40 (2):212–8.doi:10.1016/j.jhep.2003.10.008.PMID14739090.
Hirano M, Maeda K, Shitara Y, Sugiyama Y (2004). "Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans".J. Pharmacol. Exp. Ther.311 (1):139–46.doi:10.1124/jpet.104.068056.PMID15159445.S2CID9691203.
Letschert K, Keppler D, König J (2005). "Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8)".Pharmacogenetics.14 (7):441–52.doi:10.1097/01.fpc.0000114744.08559.92.PMID15226676.
Ohtsuka H, Abe T, Onogawa T, et al. (2006). "Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene".J. Gastroenterol.41 (4):369–77.doi:10.1007/s00535-006-1784-3.PMID16741617.S2CID7626543.
Mahagita C, Grassl SM, Piyachaturawat P, Ballatori N (2007). "Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport".Am. J. Physiol. Gastrointest. Liver Physiol.293 (1): G271–8.doi:10.1152/ajpgi.00075.2007.PMID17412826.
Treiber A, Schneiter R, Häusler S, Stieger B (2007). "Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil".Drug Metab. Dispos.35 (8):1400–7.doi:10.1124/dmd.106.013615.PMID17496208.S2CID2625368.
