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Sodium–hydrogen antiporter 1

From Wikipedia, the free encyclopedia
(Redirected fromSLC9A1)
Protein-coding gene in the species Homo sapiens
SLC9A1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1Y4E,2BEC,2E30,2KBV,2L0E,2MDF,2YGG

Identifiers
AliasesSLC9A1, APNH, NHE-1, NHE1, PPP1R143, LIKNS, Sodium–hydrogen antiporter 1, solute carrier family 9 member A1
External IDsOMIM:107310;MGI:102462;HomoloGene:20660;GeneCards:SLC9A1;OMA:SLC9A1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SLC9A1
Genomic location for SLC9A1
Band1p36.11Start27,098,809bp[1]
End27,166,981bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for SLC9A1
Genomic location for SLC9A1
Band4 D2.3|4 66.25 cMStart133,097,017bp[2]
End133,151,013bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • mucosa of transverse colon

  • oocyte

  • placenta

  • body of stomach

  • stromal cell of endometrium

  • pylorus

  • putamen

  • mucosa of urinary bladder

  • nasal epithelium
Top expressed in
  • epithelium of stomach

  • zygote

  • ankle joint

  • pyloric antrum

  • secondary oocyte

  • mucous cell of stomach

  • gastrula

  • granulocyte

  • decidua

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6548

20544

Ensembl

ENSG00000090020

ENSMUSG00000028854

UniProt

P19634

Q61165

RefSeq (mRNA)

NM_003047

NM_016981
NM_001358455

RefSeq (protein)

NP_003038

NP_058677
NP_001345384

Location (UCSC)Chr 1: 27.1 – 27.17 MbChr 4: 133.1 – 133.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thesodium-hydrogen antiporter 1 (NHE-1) also known assodium/hydrogen exchanger 1 orSLC9A1 (SoLute Carrier family 9A1) is an isoform ofsodium–hydrogen antiporter that in humans is encoded by theSLC9A1gene.[5]

Function

[edit]

The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drugamiloride and activated by a variety of signals includinggrowth factors,mitogens,neurotransmitters,tumor promoters, and others.[6]

Interactions

[edit]

Sodium–hydrogen antiporter 1 has been shown tointeract withcarbonic anhydrase II[7] andCHP.[8][9][10] It is also the target of the experimental drugrimeporide, which is being developed for the treatment ofDuchenne muscular dystrophy.[11]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000090020 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000028854 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (August 1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger".Molecular and Cellular Biochemistry.125 (2):137–43.doi:10.1007/BF00936442.PMID 8283968.S2CID 24360200.
  6. ^Cardone RA, Alfarouk KO, Elliott RL, Alqahtani SS, Ahmed SB, Aljarbou AN, et al. (July 2019)."The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela".International Journal of Molecular Sciences.20 (15): 3694.doi:10.3390/ijms20153694.PMC 6696090.PMID 31357694.
  7. ^Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L (September 2002)."Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger".The Journal of Biological Chemistry.277 (39):36085–91.doi:10.1074/jbc.M111952200.PMID 12138085.
  8. ^Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (February 2003)."Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium".Biological & Pharmaceutical Bulletin.26 (2):148–55.doi:10.1248/bpb.26.148.PMID 12576672.
  9. ^Lin X, Barber DL (October 1996)."A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange".Proceedings of the National Academy of Sciences of the United States of America.93 (22):12631–6.Bibcode:1996PNAS...9312631L.doi:10.1073/pnas.93.22.12631.PMC 38044.PMID 8901634.
  10. ^Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001)."Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers".The Journal of Biological Chemistry.276 (20):17367–72.doi:10.1074/jbc.M100296200.PMID 11350981.
  11. ^Spreitzer, Helmut (26 May 2015). "Rimeporide".Österreichische Apothekerzeitung (in German).69 (11): 12.

Further reading

[edit]
PDB gallery
  • 2bec: Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation
    2bec: Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation
  • 2e30: Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1
    2e30: Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1
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SLC31–40
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
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