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Zinc transporter 1

From Wikipedia, the free encyclopedia
(Redirected fromSLC30A1)
Protein found in humans

SLC30A1
Identifiers
AliasesSLC30A1, ZNT1, ZRC1, solute carrier family 30 member 1
External IDsOMIM:609521;MGI:1345281;HomoloGene:6681;GeneCards:SLC30A1;OMA:SLC30A1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SLC30A1
Genomic location for SLC30A1
Band1q32.3Start211,571,568bp[1]
End211,579,161bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for SLC30A1
Genomic location for SLC30A1
Band1 H6|1 97.01 cMStart191,638,879bp[2]
End191,645,359bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • caput epididymis

  • Epithelium of choroid plexus

  • skin of thigh

  • trabecular bone

  • dorsal motor nucleus of vagus nerve

  • vulva

  • cartilage tissue

  • corpus epididymis

  • human penis
Top expressed in
  • placenta

  • lip

  • ileum

  • renal cortex

  • proximal tubule

  • human kidney

  • primary oocyte

  • hair

  • secondary oocyte

  • jejunum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7779

22782

Ensembl

ENSG00000170385

ENSMUSG00000037434

UniProt

Q9Y6M5

Q60738

RefSeq (mRNA)

NM_021194

NM_009579

RefSeq (protein)

NP_067017

NP_033605

Location (UCSC)Chr 1: 211.57 – 211.58 MbChr 1: 191.64 – 191.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc transporter 1 is aprotein which in humans is encoded by theSLC30A1gene.[5][6]

Function

[edit]

SLC30A1 modulates zinc permeation through theL-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[7]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000170385 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000037434 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Palmiter RD, Findley SD (February 1995)."Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc".The EMBO Journal.14 (4):639–49.doi:10.1002/j.1460-2075.1995.tb07042.x.PMC 398127.PMID 7882967.
  6. ^Seve M, Chimienti F, Devergnas S, Favier A (May 2004)."In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression".BMC Genomics.5 (1): 32.doi:10.1186/1471-2164-5-32.PMC 428573.PMID 15154973.
  7. ^Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx".Biochemical and Biophysical Research Communications.323 (4):1145–50.doi:10.1016/j.bbrc.2004.08.211.PMID 15451416.

Further reading

[edit]
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Transition metal
Iron metabolism
Absorption in
duodenum
Iron(II) oxide:
Iron(III) oxide:
Other
Iron-binding proteins:
Copper metabolism
Zinc metabolism
Electrolyte
Sodium metabolism
Phosphate metabolism
Magnesium metabolism
Calcium metabolism


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