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Mitochondrial 2-oxodicarboxylate carrier

From Wikipedia, the free encyclopedia
(Redirected fromSLC25A21)
Protein-coding gene in the species Homo sapiens
SLC25A21
Identifiers
AliasesSLC25A21, ODC, ODC1, solute carrier family 25 member 21, MTDPS18
External IDsOMIM:607571;MGI:2445059;HomoloGene:6988;GeneCards:SLC25A21;OMA:SLC25A21 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SLC25A21
Genomic location for SLC25A21
Band14q13.3Start36,677,921bp[1]
End37,172,606bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for SLC25A21
Genomic location for SLC25A21
Band12|12 C1Start56,759,419bp[2]
End57,244,257bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • testicle

  • stromal cell of endometrium

  • gastric mucosa

  • popliteal artery

  • tibial arteries

  • bone marrow

  • right testis

  • Achilles tendon

  • smooth muscle tissue
Top expressed in
  • proximal tubule

  • bone marrow

  • right kidney

  • hepatobiliary system

  • liver

  • human kidney

  • spermatocyte

  • lobe of liver

  • morula

  • embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

89874

217593

Ensembl

ENSG00000183032

ENSMUSG00000035472

UniProt

Q9BQT8

Q8BZ09

RefSeq (mRNA)

NM_001171170
NM_030631

NM_001167976
NM_172577

RefSeq (protein)

NP_001164641
NP_085134

NP_001161448
NP_766165

Location (UCSC)Chr 14: 36.68 – 37.17 MbChr 12: 56.76 – 57.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial 2-oxodicarboxylate carrier also known assolute carrier family 25 member 21 (SLC25A21) is aprotein that in humans is encoded by theSLC25A21gene.[5]

It is a homolog of theS. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across innermitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria,2-oxoadipate is converted intoacetyl-CoA.[5]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000183032 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000035472 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ab"Solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21". Retrieved2011-12-04.

Further reading

[edit]
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
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SLC11–20
(11):
(12):
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(14):
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(17):
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SLC21–30
(21):
(22):
(23):
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(25):
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SLC31–40
(31):
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SLC41–48
(41):
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(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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