Protein-coding gene in the species Homo sapiens
Solute carrier family 22 member 7 is aprotein that in humans is encoded by thegene SLC22A7 .[ 5] [ 6] [ 7]
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organicanions , some of which are potentiallytoxic . The encoded protein is anintegral membrane protein and appears to be localized to thebasolateral membrane of thekidney . Alternatively splicedtranscript variants encoding differentisoforms have been described.[ 7]
Interactive pathway map [ edit ] Click on genes, proteins and metabolites below to link to respective articles. [ § 1]
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Fluorouracil (5-FU) Activity
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^a b c GRCh38: Ensembl release 89: ENSG00000137204 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000067144 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (Jul 1998)."Identification of multispecific organic anion transporter 2 expressed predominantly in the liver" .FEBS Lett .429 (2):179– 82.doi :10.1016/S0014-5793(98)00585-7 PMID 9650585 .S2CID 30015233 . ^ Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM (Jun 2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids".Cytogenet Cell Genet .88 (1– 2):76– 7.doi :10.1159/000015489 .PMID 10773670 .S2CID 8702529 . ^a b "Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7" .Cropp CD, Komori T, Shima JE, et al. (2008)."Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP" .Mol. Pharmacol .73 (4):1151– 8.doi :10.1124/mol.107.043117 .PMC 2698938 PMID 18216183 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" .Genome Res .16 (1):55– 65.doi :10.1101/gr.4039406 .PMC 1356129 PMID 16344560 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" .Proc. Natl. Acad. Sci. U.S.A .99 (26):16899– 903.Bibcode :2002PNAS...9916899M .doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Enomoto A, Takeda M, Shimoda M, et al. (2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors".J. Pharmacol. Exp. Ther .301 (3):797– 802.doi :10.1124/jpet.301.3.797 .PMID 12023506 . Kimura H, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins".J. Pharmacol. Exp. Ther .301 (1):293– 8.doi :10.1124/jpet.301.1.293 .PMID 11907186 .S2CID 7739298 . Babu E, Takeda M, Narikawa S, et al. (2002)."Human organic anion transporters mediate the transport of tetracycline" .Jpn. J. Pharmacol .88 (1):69– 76.doi :10.1254/jjp.88.69 PMID 11855680 . Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney".Biochem. Biophys. Res. Commun .283 (2):417– 22.doi :10.1006/bbrc.2001.4774 .PMID 11327718 . This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
By group
SLC1–10
(1): (2): (3): (4): (5): (6): (7): (8): (9): (10):
SLC11–20
(11): (12): (13): (14): (15): (16): (17): (18): (19): (20):
SLC21–30
(21): (22): (23): (24): (25): (26): (27): (28): (29): (30):
SLC31–40
(31): (32): (33): (34): (35): (36): (37): (38): (39): (40):
SLC41–48
(41): (42): (43): (44): (45): (46): (47): (48):
