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SLC22A2

From Wikipedia, the free encyclopedia
Protein-coding gene
SLC22A2
Identifiers
AliasesSLC22A2, OCT2, solute carrier family 22 member 2
External IDsOMIM:602608;MGI:1335072;HomoloGene:68293;GeneCards:SLC22A2;OMA:SLC22A2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SLC22A2
Genomic location for SLC22A2
Band6q25.3Start160,171,061bp[1]
End160,277,638bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for SLC22A2
Genomic location for SLC22A2
Band17 A1|17 8.61 cMStart12,803,019bp[2]
End12,847,375bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • kidney tubule

  • renal medulla

  • human kidney

  • testicle

  • glomerulus

  • metanephric glomerulus

  • buccal mucosa cell

  • oocyte

  • secondary oocyte

  • right coronary artery
Top expressed in
  • right kidney

  • proximal tubule

  • human kidney

  • yolk sac

  • proximal convoluted tubule

  • proximal straight tubule

  • respiratory epithelium

  • olfactory epithelium

  • sciatic nerve

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6582

20518

Ensembl

ENSG00000112499

ENSMUSG00000040966

UniProt

O15244

O70577

RefSeq (mRNA)

NM_153191
NM_003058

NM_013667
NM_001355767

RefSeq (protein)

NP_003049

NP_038695
NP_001342696

Location (UCSC)Chr 6: 160.17 – 160.28 MbChr 17: 12.8 – 12.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 22 member 2 (also termedOCT2 ororganic cation transporter-2[5]) is aprotein that in humans is encoded by theSLC22A2gene.[6][7]

Poly specific organic cation transporters in the liver, kidney, intestine, and other organs are important for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.[7]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000112499 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000040966 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"SLC22A2 solute carrier family 22 member 2 [Homo sapiens (human)] - Gene - NCBI".
  6. ^Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26".Cytogenet Cell Genet.79 (3–4):198–200.doi:10.1159/000134720.PMID 9605850.
  7. ^ab"Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2".

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

By group
SLC1–10
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SLC11–20
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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