Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.[6]
It is also required for the uptake ofmetformin by cells.[7][8]
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^Rosilio C, Ben-Sahra I, Bost F, Peyron J (1 May 2014). "Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia".Cancer Letters.346 (2):188–196.doi:10.1016/j.canlet.2014.01.006.PMID24462823.
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