Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Folate transporter 1

From Wikipedia, the free encyclopedia
(Redirected fromSLC19A1)
Mammalian protein found in Homo sapiens

SLC19A1
Identifiers
AliasesSLC19A1, CHMD, FOLT, IFC1, REFC, RFC1, solute carrier family 19 member 1, IFC-1, RFC, hRFC, RFT-1, hMEGAF
External IDsOMIM:600424;MGI:103182;HomoloGene:57139;GeneCards:SLC19A1;OMA:SLC19A1 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for SLC19A1
Genomic location for SLC19A1
Band21q22.3Start45,493,572bp[1]
End45,573,365bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SLC19A1
Genomic location for SLC19A1
Band10 C1|10 39.72 cMStart77,032,241bp[2]
End77,061,002bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • blood

  • endothelial cell

  • Epithelium of choroid plexus

  • retinal pigment epithelium

  • duodenum

  • gallbladder

  • stromal cell of endometrium

  • right lung

  • putamen
Top expressed in
  • Paneth cell

  • right kidney

  • retinal pigment epithelium

  • vestibular membrane of cochlear duct

  • choroid plexus of fourth ventricle

  • ciliary body

  • Epithelium of choroid plexus

  • human kidney

  • crypt of lieberkuhn of small intestine

  • endothelial cell of lymphatic vessel
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6573

20509

Ensembl

ENSG00000173638

ENSMUSG00000001436

UniProt

P41440

P41438

RefSeq (mRNA)
NM_001205206
NM_001205207
NM_003056
NM_194255
NM_001352510

NM_001352511
NM_001352512

NM_001199271
NM_031196

RefSeq (protein)
NP_001192135
NP_001192136
NP_919231
NP_001339439
NP_001339440

NP_001339441

NP_001186200
NP_112473

Location (UCSC)Chr 21: 45.49 – 45.57 MbChr 10: 77.03 – 77.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Folate transporter 1 is aprotein which in humans is encoded by theSLC19A1gene.[5]

Function

[edit]

Transport offolate compounds into mammalian cells can occur via receptor-mediated (seefolate receptor 1) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types.Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[6] SLC19A1 has also been shown to transport the immune second messenger2'3'-cGAMP.[7]

Clinical significance

[edit]

Individuals carrying a specificpolymorphism of SLC19A1 (c.80GG) have lower levels of folate.[8] Other studies have also shown that individuals carrying the c.80AA polymorphism who are treated with methotrexate have higher levels of this anti-folate chemotherapeutic agent. Personalized dosing of the drug depending on the patient's genotype may therefore be required.

Alternative names

[edit]
  • Reduced folate carrier 1
  • Intestinal folate carrier 1

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000173638 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000001436 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Lapenta V, Sossi V, Gosset P, Vayssettes C, Vitali T, Rabatel N, et al. (April 1998). "Construction of a 2.5-Mb integrated physical and gene map of distal 21q22.3".Genomics.49 (1):1–13.doi:10.1006/geno.1997.5185.PMID 9570943.
  6. ^"Entrez Gene: SLC19A1 solute carrier family 19 (folate transporter), member 1".
  7. ^Ritchie C, Cordova A, Hess G, Bassik M, Li L (25 July 2019)."SLC19A1 Is an Importer of the Immunotransmitter cGAMP".Molecular Cell.75 (2): 372–381.e5.doi:10.1016/j.molcel.2019.05.006.PMC 6711396.PMID 31126740.
  8. ^Stanisławska-Sachadyn A, Mitchell LE, Woodside JV, Buckley PT, Kealey C, Young IS, et al. (September 2009)."The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women".Annals of Human Genetics.73 (Pt 5):484–491.doi:10.1111/j.1469-1809.2009.00529.x.PMC 2812009.PMID 19650776.

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Retrieved from "https://en.wikipedia.org/w/index.php?title=Folate_transporter_1&oldid=1318019910"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp