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SLC16A11

From Wikipedia, the free encyclopedia
SLC16A11
Identifiers
AliasesSLC16A11, MCT11, solute carrier family 16 member 11, MCT 11
External IDsOMIM:615765;MGI:2663709;HomoloGene:27409;GeneCards:SLC16A11;OMA:SLC16A11 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SLC16A11
Genomic location for SLC16A11
Band17p13.1Start7,041,621bp[1]
End7,044,092bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SLC16A11
Genomic location for SLC16A11
Band11|11 B3Start70,103,578bp[2]
End70,107,243bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • olfactory zone of nasal mucosa

  • parotid gland

  • minor salivary glands

  • palpebral conjunctiva

  • skin of abdomen

  • skin of leg

  • right lobe of liver
Top expressed in
  • cerebellar cortex

  • right kidney

  • olfactory epithelium

  • motor neuron

  • superior frontal gyrus

  • trachea

  • primary visual cortex

  • conjunctival fornix

  • dentate gyrus of hippocampal formation granule cell

  • gastrula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

162515

216867

Ensembl

ENSG00000174326

ENSMUSG00000040938

UniProt

Q8NCK7

Q5NC32

RefSeq (mRNA)

NM_153357
NM_001370549
NM_001370553

NM_001114970
NM_001114971
NM_153081

RefSeq (protein)

NP_699188
NP_001357478
NP_001357482

NP_694721

Location (UCSC)Chr 17: 7.04 – 7.04 MbChr 11: 70.1 – 70.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Monocarboxylate transporter 11 (MCT 11) is aprotein that in humans is encode by theSLC16A11gene.[5]

Variants in this gene are associated with increasedbody-mass index[6] andtype 2 diabetes.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000174326Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000040938Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"UniProt".www.uniprot.org. Retrieved2024-07-16.
  6. ^Mardones L, Petermann-Rocha F, Martinez-Sanguinetti MA, Leiva AM, Troncoso-Pantoja C, Martorell M, et al. (November 2021)."Genetic variants in theSLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population".Archives of Endocrinology and Metabolism.65 (3):305–314.doi:10.20945/2359-3997000000359.PMC 10065347.PMID 33909378.
  7. ^Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, et al. (February 2014)."Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico".Nature.506 (7486):97–101.Bibcode:2014Natur.506...97T.doi:10.1038/nature12828.PMC 4127086.PMID 24390345.
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