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SIRPG

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SIRPG
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2JJW,4I2X

Identifiers
AliasesSIRPG, CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma
External IDsOMIM:605466;MGI:108563;HomoloGene:56809;GeneCards:SIRPG;OMA:SIRPG - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SIRPG
Genomic location for SIRPG
Band20p13Start1,629,152bp[1]
End1,657,779bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SIRPG
Genomic location for SIRPG
Band2 F1|2 63.19 cMStart129,434,755bp[2]
End129,474,148bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • thymus

  • testicle

  • lymph node

  • granulocyte

  • blood

  • appendix

  • spleen

  • mucosa of transverse colon

  • left testis

  • right testis
Top expressed in
  • stroma of bone marrow

  • granulocyte

  • prefrontal cortex

  • superior frontal gyrus

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • cerebellar cortex

  • tibiofemoral joint

  • perirhinal cortex

  • entorhinal cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55423

19261

Ensembl

ENSG00000089012

ENSMUSG00000037902

UniProt

Q9P1W8

P97797

RefSeq (mRNA)

NM_001039508
NM_018556
NM_080816

NM_001177646
NM_001177647
NM_001291019
NM_001291020
NM_001291021

NM_001291022
NM_007547
NM_001355158
NM_001355160

RefSeq (protein)

NP_001034597
NP_061026
NP_543006

NP_001171118
NP_001277948
NP_001277949
NP_001277950
NP_001277951

NP_031573
NP_001342087
NP_001342089

Location (UCSC)Chr 20: 1.63 – 1.66 MbChr 2: 129.43 – 129.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal-regulatory protein gamma is aprotein that in humans is encoded by theSIRPGgene.[5][6][7] SIRPG has also recently been designatedCD172G (cluster of differentiation 172G).

The protein encoded by this gene is a member of thesignal-regulatory protein (SIRP) family, and also belongs to theimmunoglobulin superfamily. SIRP family members arereceptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000089012 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000037902 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M (Jan 2001)."Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family".J Hum Genet.45 (6):378–82.doi:10.1007/s100380070013.PMID 11185750.
  6. ^van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005)."A nomenclature for signal regulatory protein family members".J Immunol.175 (12):7788–9.doi:10.4049/jimmunol.175.12.7788.PMID 16339511.
  7. ^ab"Entrez Gene: SIRPG signal-regulatory protein gamma".

Further reading

[edit]

External links

[edit]
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma (SIRPG)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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