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SIB-1553A

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SIB-1553A
Names

Preferred IUPAC name 4-{[2-(1-Methylpyrrolidin-2-yl)ethyl]sulfanyl}phenol
Identifiers
CAS Number	191611-76-4^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL47850
ChemSpider	4470512
PubChem CID	5310968
UNII	TF4A9P6T8R^Y
CompTox Dashboard(EPA)	DTXSID70940803
InChI InChI=1S/C13H19NOS/c1-14-9-2-3-11(14)8-10-16-13-6-4-12(15)5-7-13/h4-7,11,15H,2-3,8-10H2,1H3 Key: NVZGJSVPOOILDI-UHFFFAOYSA-N InChI=1/C13H19NOS/c1-14-9-2-3-11(14)8-10-16-13-6-4-12(15)5-7-13/h4-7,11,15H,2-3,8-10H2,1H3 Key: NVZGJSVPOOILDI-UHFFFAOYAV
SMILES OC1=CC=C(SCCC2CCCN2C)C=C1
Properties
Chemical formula	C₁₃H₁₉NOS
Molar mass	237.36 g·mol⁻¹
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

SIB-1553A is anicotinic acetylcholine receptor agonist that is selective for receptors with aβ₄ subunit. Administration of SIB-1553A improved memory and attention in aParkinson's disease model.^[1]

^Schneider, JS (July 2003). "The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys".Journal of Pharmacology and Experimental Therapeutics.306 (1):401–6.doi:10.1124/jpet.103.051912.PMID 12721323.S2CID 7060934.

nAChRsTooltip Nicotinic acetylcholine receptors

Agonists
(and PAMsTooltip positive allosteric modulators)

Antagonists
(and NAMsTooltip negative allosteric modulators)

See also: Receptor/signaling modulators; Muscarinic acetylcholine receptor modulators; Acetylcholine metabolism/transport modulators

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