| SHC014-CoV | |
|---|---|
Virus classification | |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Pisuviricota |
| Class: | Pisoniviricetes |
| Order: | Nidovirales |
| Family: | Coronaviridae |
| Genus: | Betacoronavirus |
| Subgenus: | Sarbecovirus |
| Species: | |
| Strain: | SHC014-CoV |
| Synonyms[1] | |
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SHC014-CoV is aSARS-likecoronavirus (SL-COV) which infectshorseshoe bats (family Rhinolophidae). It was discovered inKunming inYunnan Province, China. It was discovered along with SL-CoV Rs3367, which was the first bat SARS-like coronavirus shown to directly infect a human cell line. The line of Rs3367 that infected human cells was namedBat SARS-like coronavirus WIV1.[2]
From April 2011 to September 2012, researchers from theWuhan Institute of Virology collected 117 anal swabs and fecal samples of bats from aChinese rufous horseshoe bats (Rhinolophus sinicus) colony in Kunming City (Yunnan Province in south-western China). 27 out of 117 samples (23%) contained seven different isolates of SARS-like coronaviruses, among which were two previously unknown, called RsSHC014 and Rs3367.[2]
In 2013, bat SARS-like coronavirus Rs3367 was shown to be able to directly infect the humanHeLa cell line. It was the first time that human cells had been infected with a bat SARS-like coronavirus in the lab. The strain of Rs3367 that infected the human cells was named “Bat SARS-like coronavirus WIV”.[2]
In 2015, theUniversity of North Carolina at Chapel Hill and the Wuhan Institute of Virology conducted research showing that SHC014 could be made to infect the human HeLa cell line, through the use ofreverse genetics to create achimeric virus consisting of a surface protein of SHC014 and the backbone of a SARS coronavirus.[3][4]
A phylogenetic tree based on whole-genome sequences of SARS-CoV-1 and related coronaviruses is:
| SARS‑CoV‑1 related coronavirus |
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SARS-CoV-2, 79% to SARS-CoV-1[13] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Data related toSHC014-CoV at WikispeciesTaxonomy of theCoronaviridae | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Higher taxonomy:Riboviria >Orthornavirae >Pisuviricota >Pisoniviricetes >Nidovirales >Cornidovirineae >Coronaviridae | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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