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SDB-006

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
SDB-006
Legal status
Legal status
Identifiers
  • N-benzyl-1-pentyl-1H-indole-3-carboxamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC21H24N2O
Molar mass320.436 g·mol−1
3D model (JSmol)
  • O=C(NCC1=CC=CC=C1)C2=CN(CCCCC)C3=CC=CC=C32

SDB-006 is a drug that acts as a potentagonist for thecannabinoid receptors, with an EC50 of 19 nM for human CB2 receptors, and 134 nM for human CB1 receptors.[1][2] It was discovered during research into the related compoundSDB-001 which had been sold illicitly as "2NE1".[3] SDB-006 metabolism has been described in literature.[4]

See also

[edit]

References

[edit]
  1. ^Banister SD, Stuart J, Kevin RC, Edington A, Longworth M, Wilkinson SM, Beinat C, Buchanan AS, Hibbs DE, Glass M, Connor M, McGregor IS, Kassiou M (August 2015)."Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135".ACS Chemical Neuroscience.6 (8):1445–58.doi:10.1021/acschemneuro.5b00107.PMID 25921407.
  2. ^Banister SD, Olson A, Winchester M, Stuart J, Edington AR, Kevin RC, Longworth M, Herrera M, Connor M, McGregor IS, Gerona RR, Kassiou M (January 2018). "The chemistry and pharmacology of synthetic cannabinoid SDB-006 and its regioisomeric fluorinated and methoxylated analogs".Drug Testing and Analysis.10 (7):1099–1109.doi:10.1002/dta.2362.PMID 29350472.
  3. ^Banister SD, Wilkinson SM, Longworth M, Stuart J, Apetz N, English K, et al. (July 2013)."The synthesis and pharmacological evaluation of adamantane-derived indoles: cannabimimetic drugs of abuse".ACS Chemical Neuroscience.4 (7):1081–92.doi:10.1021/cn400035r.PMC 3715837.PMID 23551277.
  4. ^Diao X, Carlier J, Scheidweiler KB, Huestis MA (July 2017). "In vitro metabolism of new synthetic cannabinoid SDB-006 in human hepatocytes by high-resolution mass spectrometry".Forensic Toxicology.35 (2):252–262.doi:10.1007/s11419-016-0350-9.S2CID 26558377.
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