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SCN2B

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

SCN2B

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
5FEB,5FDY

Identifiers

Aliases

SCN2B, ATFB14, sodium voltage-gated channel beta subunit 2

External IDs

OMIM:601327;MGI:106921;HomoloGene:3373;GeneCards:SCN2B;OMA:SCN2B - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q23.3	Start	118,162,806bp^[1]
Band	11q23.3	End	118,176,639bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 A5.2\|9 24.84 cM	Start	45,029,080bp^[2]
Band	9 A5.2\|9 24.84 cM	End	45,041,368bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

middle temporal gyrus

lateral nuclear group of thalamus

cerebellar cortex

cerebellar hemisphere

prefrontal cortex

right hemisphere of cerebellum

cerebellar vermis

superior frontal gyrus

primary visual cortex

right frontal lobe

Top expressed in

lobe of cerebellum

cerebellar vermis

lateral geniculate nucleus

olfactory tubercle

superior colliculus

medial geniculate nucleus

habenula

lateral septal nucleus

lateral hypothalamus

medial dorsal nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	voltage-gated sodium channel activity involved in cardiac muscle cell action potential sodium channel regulator activity sodium channel activity voltage-gated sodium channel activity voltage-gated ion channel activity
Cellular component	integral component of membrane voltage-gated sodium channel complex membrane
Biological process	chemical synaptic transmission nervous system development cardiac muscle cell action potential involved in contraction sodium ion transport sodium ion transmembrane transport regulation of sodium ion transmembrane transporter activity cardiac muscle contraction regulation of heart rate by cardiac conduction regulation of atrial cardiac muscle cell membrane depolarization membrane depolarization during cardiac muscle cell action potential regulation of ion transmembrane transport ion transport response to pyrethroid
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


6327


72821

Ensembl


ENSG00000149575


ENSMUSG00000070304

UniProt


O60939


Q56A07

RefSeq (mRNA)


NM_004588


NM_001014761

RefSeq (protein)


NP_004579


NP_001014761

Location (UCSC)

Chr 11: 118.16 – 118.18 Mb

Chr 9: 45.03 – 45.04 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sodium channel subunit beta-2 is aprotein that in humans is encoded by theSCN2Bgene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000149575 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000070304 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes".Genomics.57 (2):323–31.doi:10.1006/geno.1998.5735.PMID 10198179.
^"Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta".

External links

[edit]

SCN2B+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
Overview of all the structural information available in thePDB forUniProt:O60939 (Sodium channel subunit beta-2) at thePDBe-KB.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin