Sodium channel subunit beta-1 is aprotein that in humans is encoded by theSCN1Bgene.[5][6]
Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM][6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^McClatchey AI, Cannon SC, Slaugenhaupt SA, Gusella JF (Sep 1993). "The cloning and expression of a sodium channel beta 1-subunit cDNA from human brain".Hum Mol Genet.2 (6):745–9.doi:10.1093/hmg/2.6.745.PMID8394762.
Makita N, Sloan-Brown K, Weghuis DO, et al. (1995). "Genomic organization and chromosomal assignment of the human voltage-gated Na+ channel beta 1 subunit gene (SCN1B)".Genomics.23 (3):628–34.doi:10.1006/geno.1994.1551.PMID7851891.
Wallace RH, Wang DW, Singh R, et al. (1998). "Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B".Nat. Genet.19 (4):366–70.doi:10.1038/1252.PMID9697698.S2CID20962841.
Aronica E, Troost D, Rozemuller AJ, et al. (2003). "Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies".Acta Neuropathol.105 (5):515–23.doi:10.1007/s00401-003-0677-2.hdl:2027.42/42208.PMID12677453.S2CID30847819.
Qin N, D'Andrea MR, Lubin ML, et al. (2004). "Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit".Eur. J. Biochem.270 (23):4762–70.doi:10.1046/j.1432-1033.2003.03878.x.PMID14622265.
