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| Formula | C17H18N2O3S |
| Molar mass | 330.40 g·mol−1 |
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SB-205384 is ananxiolytic drug. It has similar effects tobenzodiazepine drugs, but is structurally distinct and so is classed as anonbenzodiazepine anxiolytic.
SB-205384 is aGABAApositive allosteric modulator, which binds preferentially to α3, α5, and α6 subunit containing subtypes.[1][2] It has a novel mechanism of action, prolonging the duration of GABA-mediated chloride flux but without increasing the intensity of the response, and this may give it an unusual pharmacological profile,[3] with tests showing that it alters the firing of some populations of neurons while leaving others unaffected.[4] Animal studies have shown it to produce both anxiolytic and anti-aggressive effects, but with little sedation or other behavioural changes.[5][6]
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