Sphingosine-1-phosphate receptor 4 also known asS1PR4 is a humangene which encodes aG protein-coupled receptor which binds the lipid signaling moleculesphingosine 1-phosphate (S1P). Hence this receptor is also known asS1P4.[5]
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.[5]
Gräler MH, Bernhardt G, Lipp M (1998). "EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue".Genomics.53 (2):164–9.doi:10.1006/geno.1998.5491.PMID9790765.
Yamazaki Y, Kon J, Sato K, et al. (2000). "Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway".Biochem. Biophys. Res. Commun.268 (2):583–9.doi:10.1006/bbrc.2000.2162.PMID10679247.
Van Brocklyn JR, Gräler MH, Bernhardt G, et al. (2000). "Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6".Blood.95 (8):2624–9.doi:10.1182/blood.V95.8.2624.PMID10753843.S2CID12111192.
Candelore MR, Wright MJ, Tota LM, et al. (2002). "Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor".Biochem. Biophys. Res. Commun.297 (3):600–6.doi:10.1016/S0006-291X(02)02237-4.PMID12270137.
Gräler MH, Grosse R, Kusch A, et al. (2003). "The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13".J. Cell. Biochem.89 (3):507–19.doi:10.1002/jcb.10537.PMID12761884.S2CID2164285.
Kyi CS, Key SJ, Lloyd TW (2003). "Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm".International Journal of Oral and Maxillofacial Surgery.32 (3):337–8.doi:10.1054/ijom.2003.0364.PMID12767884.
"Lysophospholipid Receptors: S1P4".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-05.
