It is noted for its largeochre deposits found in the clay surrounding the village. Ochres are pigments ranging from yellow and orange to red. One of the former ochre quarries can be visited via the "Sentier des Ocres" (Ochre Path), a walk of either 30 or 60 minutes through the old workings.
The village stands on an ochre ridge, situated in a broad valley with the "Monts du Vaucluse" to the north and the "Petit" Luberon to the south. The nearest railway station is in Cavaillon; the nearestTGV station is inAvignon.
The riverCalavon forms part of the commune's southern border.
Roussillon is famous for the rich deposits of ochre pigments found in the clay near the village. The large quarries of Roussillon were mined from the end of the 18th century until 1930. Thousands of people found work in the quarries and factories. Nowadays the mining of ochre is prohibited here, in order to protect the sites from degradation or even complete destruction.
During the 18th century, increasing demand for pigments in the textile industry led to intensified mining ofochres in Roussillon. Numerous quarries and ochre factories, some of which can still be seen today, were situated near the village. One example of an ochre factory, the "Usine Mathieu", is named for the family that owned it from 1870 to 1901. It has been formed into a "Conservatoire": a workshop serving as a museum. The quarries and factories were established in the villages of Roussillon,Villars,Gargas,Rustrel (with itsColorado provençal) andGignac.
During the 20th century, mining techniques were modernized, which meant that more profitableochre mines became exploitable. This resulted in a gradual closing-down of ochre mines in and around Roussillon. From the 1980s, tourism has replaced the ochre industry as a source of income.[4]
Apart from tourism, agriculture is the commune's principal activity. Fruit, including cherries, peaches and melons are grown. Much of this is used in crystallized fruit production in nearbyApt. Wine-making is very important and there are severalwineries producing red,rosé, and white wines within theVentoux AOC.
The Irish writerSamuel Beckett went into hiding from the Nazis in Roussillon during the years 1942–1945. His novelWatt was written there, and Beckett mentioned the village in his famous playWaiting for Godot (En attendant Godot) (1955).
Under the name of Peyrane, Roussillon is the subject ofLaurence Wylie,Village in the Vaucluse (first edition 1957.)
Roussillon is the setting ofSusan Vreeland's 2015 novel,Lisette's List, about a young couple who move from Paris to Roussillon in 1937 to live with the husband's aging grandfather, an ochre miner and pigment salesman, who owns several post-impressionist paintings.