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Rontalizumab

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Rontalizumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized
TargetIFN-α
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6486H9990N1722O2026S44
Molar mass145917.93 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Rontalizumab is ahumanizedmonoclonal antibody[1] being developed byGenentech.[2] As of November 2009[update], it is being investigated in aclinical trial for the treatment ofsystemic lupus erythematosus.[3][4]

References

[edit]
  1. ^WHO Drug Information
  2. ^Genentech: Rontalizumab (rhuMAb IFN alpha)
  3. ^Clinical trial numberNCT00962832 for "A Study to Evaluate the Efficacy and Safety of Rontalizumab in Patients With Moderately to Severely Active Systemic Lupus Erythematosus (ROSE)" atClinicalTrials.gov
  4. ^Misra DP, Negi VS (March 2017)."Interferon targeted therapies in systemic lupus erythematosus".Mediterranean Journal of Rheumatology.28 (1):13–19.doi:10.31138/mjr.28.1.13.PMC 7045923.PMID 32185249.
Immune system
Human
Mouse
Chimeric
Humanized
Chimeric + humanized
Interleukin
Human
Humanized
Veterinary
Inflammatorylesions
Mouse
Chemokine
CSF
Erythropoietin
G-CSF (CSF3)
GM-CSF (CSF2)
M-CSF (CSF1)
SCF (c-Kit)
Thrombopoietin
Interferon
IFNAR (α/β, I)
IFNGR (γ, II)
IFNLR (λ, III)
  • See IL-28R (IFNLR)here instead.
Interleukin
TGFβ
TNF
Others
JAK
(inhibitors)
JAK1
JAK2
JAK3
TYK2
Others


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