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Ronifibrate

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Chemical compound

Pharmaceutical compound

Ronifibrate
Clinical data

Other names	3-[(pyridin-3-yl)carbonyloxy]propyl 2-(4-chlorophenoxy)-2-methylpropanoate
ATC code	C10AB07 (WHO)
Identifiers
IUPAC name 3-{[2-(4-chlorophenoxy)-2-methylpropanoyl]oxy}propyl nicotinate
CAS Number	42597-57-9^N
PubChemCID	68671
ChemSpider	61925^Y
UNII	W86I18X716
ChEMBL	ChEMBL153983^Y
CompTox Dashboard(EPA)	DTXSID80195362
Chemical and physical data
Formula	C₁₉H₂₀ClNO₅
Molar mass	377.82 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(OCCCOC(=O)C(Oc1ccc(Cl)cc1)(C)C)c2cccnc2
InChI InChI=1S/C19H20ClNO5/c1-19(2,26-16-8-6-15(20)7-9-16)18(23)25-12-4-11-24-17(22)14-5-3-10-21-13-14/h3,5-10,13H,4,11-12H2,1-2H3^Y Key:AYJVGKWCGIYEAK-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Ronifibrate is afibrate, ahypolipidemic agent. It is a combinedester ofclofibric acid andniacin (nicotinic acid) with1,3-propanediol. In the body, the ester issplit to 1,3-propanediol and both acids which work in the same way, loweringlipids in blood.

References

[edit]

Lipid-lowering agents (C10)

GI tract

Cholesterol absorption inhibitors,NPC1L1	Ezetimibe Hyzetimibe SCH-48461
Bile acid sequestrants/resins (LDL)	Colesevelam Colestilan Colestipol Colestyramine Colextran Soluble fiber such aspsyllium andglucomannan

Liver

Statins (HMG-CoA reductase,LDL)	Atorvastatin Cerivastatin^‡ Fluvastatin Lovastatin Mevastatin Pitavastatin Pravastatin Rosuvastatin Simvastatin^#
Niacin and derivatives (HDL andLDL)	Acipimox Aluminium nicotinate Nicotinic acid Niceritrol Nicofuranose Nicotinyl alcohol
MTTP inhibitors (VLDL)	Dirlotapide Lomitapide Mitratapide
ATP citrate lyase inhibitors (LDL)	Bempedoic acid
Thyromimetics (VLDL)	Dextrothyroxine^‡ Resmetirom

Blood vessels

PPAR agonists (LDL)

Fibrates	Aluminium clofibrate Bezafibrate Choline fenofibrate Ciprofibrate Clinofibrate Clofibrate^‡ Clofibride Etofibrate Fenofibrate Gemfibrozil Nafenopin Pemafibrate Ronifibrate Simfibrate
Others	GW501516^§

CETP inhibitors (HDL)

PCSK9 inhibitors (LDL)

ANGPTL3 inhibitors (LDL/HDL)

Evinacumab

Combinations

Other

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

v t e PPARTooltip Peroxisome proliferator-activated receptormodulators
PPARαTooltip Peroxisome proliferator-activated receptor alpha	Agonists:15-HETE 15-HpETE Aleglitazar Aluminium clofibrate Arachidonic acid Bezafibrate Chiglitazar Clofibrate CP-775146 Daidzein DHEA (prasterone) (in rodents) Elafibranor Etomoxir Fenofibrate Genistein Gemfibrozil GW-7647 Lanifibranor Leukotriene B₄ LG-101506 LG-100754 Lobeglitazone Muraglitazar Oleylethanolamide Palmitoylethanolamide Pemafibrate Perfluorononanoic acid Perfluorooctanoic acid Pioglitazone Saroglitazar Sodelglitazar Tesaglitazar Tetradecylthioacetic acid Troglitazone WY-14643 Antagonists:GW-6471 MK-886
PPARδTooltip Peroxisome proliferator-activated receptor delta	Agonists:15-HETE 15-HpETE Arachidonic acid Bezafibrate Daidzein Elafibranor Fonadelpar Genistein GW-0742 GW-501516 L-165,041 Lanifibranor LG-101506 Seladelpar Sodelglitazar Tetradecylthioacetic acid Antagonists:FH-535 GSK-0660 GSK-3787
PPARγTooltip Peroxisome proliferator-activated receptor gamma	Agonists:5-Oxo-ETE 5-Oxo-15-hydroxy-ETE 15-Deoxy-Δ^12,14-prostaglandin J₂ 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Chiglitazar Ciglitazone Daidzein Darglitazone Edaglitazone Efatutazone Englitazone Etalocib Farglitazar Genistein GW-1929 Ibuprofen Imiglitazar Indeglitazar Lanifibranor LG-100268 LG-100754 LG-101506 Lobeglitazone Muraglitazar (muroglitazar) nTZDpa Naveglitazar Netoglitazone Oxeglitazar Peliglitazar Pemaglitazar Perfluorononanoic acid Pioglitazone Prostaglandin J₂ Ragaglitazar Reglitazar Rivoglitazone Rosiglitazone RS5444 Saroglitazar Sipoglitazar Sodelglitazar Telmisartan Tesaglitazar Troglitazone SPPARMsTooltip Selective PPARγ modulator:BADGE EPI-001 INT-131 MK-0533 S26948 Antagonists:FH-535 GW-9662 SR-202 T-0070907 Unknown:SR-1664
Non-selective	Agonists:Ciprofibrate Clinofibrate Clofibride Englitazone Etofibrate Farglitazar Netoglitazone Ronifibrate Rivoglitazone Simfibrate
See also Receptor/signaling modulators

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