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Roluperidone

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Roluperidone
Clinical data
Other namesMIN-101; CYR-101; MT-210
Routes of
administration		By mouth
Identifiers
  • 2-[[1-[2-(4-Fluorophenyl)-2-oxoethyl]piperidin-4-yl]methyl]-3H-isoindol-1-one
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H23FN2O2
Molar mass366.436 g·mol−1
3D model (JSmol)
  • C1CN(CCC1CN2CC3=CC=CC=C3C2=O)CC(=O)C4=CC=C(C=C4)F
  • InChI=1S/C22H23FN2O2/c23-19-7-5-17(6-8-19)21(26)15-24-11-9-16(10-12-24)13-25-14-18-3-1-2-4-20(18)22(25)27/h1-8,16H,9-15H2
  • Key:RNRYULFRLCBRQS-UHFFFAOYSA-N

Roluperidone (former developmental code namesMIN-101,CYR-101,MT-210) is a5-HT2A andσ2 receptorantagonist under development byMinerva Neurosciences for the treatment ofschizophrenia.[1][2][3][4] One of itsmetabolites also has someaffinity for theH1 receptor.[2] Pre-clinical findings provide evidence of the effect of roluperidone onbrain-derived neurotrophic factor ("BDNF"), which has been associated with neurogenesis, neuroplasticity, neuroprotection, synapse regulation, learning and memory.[5]

As of May 2018, the drug was inphase IIIclinical trials.[6] In May 2020, the shares of Minerva Neurosciences plummeted 67% after the trial "failed to meet its primary endpoint of reduction in negative symptoms, and key secondary endpoints of improvement in personal and social performance measurements."[7] However, in August 2022 Minerva submitted a New Drug Application (NDA) to theFood and Drug Administration (FDA) for the approval of roluperidone for the treatment ofschizophrenia.[8] The NDA submission in 2022 followed successful completion of a phase III clinical trial which was published in early 2022. Minerva believed that the findings of this second trial supported the claim that the drug was an effective agent for the treatment of negative symptoms in schizophrenia. However, in October 2022, FDA sent Minerva a refusal to file letter pertaining to the New Drug Application for roluperidone for treating negative symptoms in schizophrenia patients.[9]

Chemistry

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Synthesis

[edit]
Patents:[10][11] Precursor:[12]

The Boc protection of 4-aminomethylpiperidine [7144-05-0] (1) gives tert-Butyl 4-aminomethylpiperidine-1-carboxylate hydrochloride [359629-16-6] (2). The free-radical halogenation of ethyl o-toluate [87-24-1] (3) led to ethyl 2-(bromomethyl)benzoate [7115-91-5] (4). The reaction between the two intermediates led to 2-[(1-tert-Butoxycarbonylpiperidin-4-yl)methyl]isoindolin-1-one [359629-19-9] (5). Deprotection yielded 2-(Piperidin-4-ylmethyl)-3H-isoindol-1-one;hydrochloride (6). Alkylation of the secondary nitrogen with 2-chloro-4'-fluoroacetophenone [700-35-6] (7) completed the synthesis ofRoluperidone (8).

See also

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References

[edit]
  1. ^Mestre TA, Zurowski M, Fox SH (April 2013). "5-Hydroxytryptamine 2A receptor antagonists as potential treatment for psychiatric disorders".Expert Opinion on Investigational Drugs.22 (4):411–21.doi:10.1517/13543784.2013.769957.PMID 23409724.S2CID 36268341.
  2. ^abEbdrup BH, Rasmussen H, Arnt J, Glenthøj B (September 2011). "Serotonin 2A receptor antagonists for treatment of schizophrenia".Expert Opinion on Investigational Drugs.20 (9):1211–23.doi:10.1517/13543784.2011.601738.PMID 21740279.S2CID 438422.
  3. ^Köster LS, Carbon M, Correll CU (December 2014). "Emerging drugs for schizophrenia: an update".Expert Opinion on Emerging Drugs.19 (4):511–31.doi:10.1517/14728214.2014.958148.PMID 25234340.S2CID 42729570.
  4. ^"Drug Development in Schizophrenia: Summary and Table".Pharmaceutical Medicine.28 (5):265–271. 2014.doi:10.1007/s40290-014-0070-6.ISSN 1178-2595.S2CID 256364393.
  5. ^"Roluperidone (MIN-101) • Minerva Neurosciences".
  6. ^"Roluperidone - Minerva Neurosciences".Adis Insight. Springer Nature Switzerland AG.
  7. ^Kilgore T (29 May 2020)."Minerva Neurosciences' stock plummets after schizophrenia treatment disappoints in phase 3 study".MarketWatch. Retrieved2021-03-21.
  8. ^"Minerva Neurosciences Submits New Drug Application to FDA for Roluperidone for the Treatment of Negative Symptoms in Patients with Schizophrenia". 22 August 2022.
  9. ^"Minerva Neurosciences Receives Refusal to File Letter from FDA for its New Drug Application for Roluperidone for the Treatment of Negative Symptoms in Schizophrenia".
  10. ^Haruko Yamabe, et al.U.S. patent 7,166,617 (2003 to Mitsubishi Pharma Corp).
  11. ^Haruko Yamabe, et al.U.S. patent 20,030,212,094 (2003 to Mitsubishi Pharma Corp).
  12. ^Prugh, J. D., Birchenough, L. A., Egbertson, M. S. (August 1992). "A Simple Method of Protecting a Secondary Amine with Tert Butyloxycarbonyl (Boc) in the Presence of a Primary Amine". Synthetic Communications. 22 (16): 2357–2360. doi:10.1080/00397919208019091.
Typical
Disputed
Atypical
Others
H1
Agonists
Antagonists
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
σ1
σ2
Unsorted
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