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Rofleponide

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Rofleponide
Clinical data
Other names6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic (R)-16,17-acetal with butyraldehyde; 16α,17α-[(1R)-butylidenebis(oxy)]-6α,9α-difluoro-11β,21-dihydroxypregn-4-ene-3,20-dione
Drug classCorticosteroid;Glucocorticoid
Identifiers
  • (4aS,4bR,5S,6aS,6bS,8R,9aR,10aS,10bS,12S)-4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8-propyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC25H34F2O6
Molar mass468.538 g·mol−1
3D model (JSmol)
  • CCC[C@@H]1O[C@@H]2C[C@H]3[C@@H]4C[C@@H](C5=CC(=O)CC[C@@]5([C@]4([C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)F)C)F
  • InChI=1S/C25H34F2O6/c1-4-5-21-32-20-10-14-15-9-17(26)16-8-13(29)6-7-22(16,2)24(15,27)18(30)11-23(14,3)25(20,33-21)19(31)12-28/h8,14-15,17-18,20-21,28,30H,4-7,9-12H2,1-3H3/t14-,15-,17-,18-,20+,21+,22-,23-,24-,25+/m0/s1
  • Key:IXTCZMJQGGONPY-XJAYAHQCSA-N

Rofleponide is asyntheticglucocorticoidcorticosteroid which was never marketed.[1][2][3][4]

References

[edit]
  1. ^"Rofleponide". AdisInsight.
  2. ^Ahlström-Emanuelsson C, Andersson M, Persson C, Schrewelius C, Greiff L (2004). "Topical treatment with aqueous solutions of rofleponide palmitate and budesonide in a pollen-season model of allergic rhinitis".Clin. Exp. Allergy.34 (5):731–5.doi:10.1111/j.1365-2222.2004.1965.x.PMID 15144464.S2CID 1480600.
  3. ^K Nagaraju (30 November 2013).Manual of Pediatric Allergy. JP Medical Ltd. pp. 109–.ISBN 978-93-5090-498-5.
  4. ^Jonathan A. Bernstein (27 May 2016).Rhinitis, An Issue of Immunology and Allergy Clinics of North America, E-Book. Elsevier Health Sciences. pp. 407–.ISBN 978-0-323-44468-2.
GRTooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others


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