Robert C. Green is an American medical geneticist, physician, and public health researcher. He directs the Genomes2People Research Program in translational genomics and health outcomes in the Division of Genetics atBrigham and Women's Hospital and theBroad Institute, and is Director of the Preventive Genomics Clinic atBrigham and Women's Hospital.[1] Research led by Green includes clinical and research aspects of genomic and precision medicine, including the development and disclosure of Alzheimer's disease risk estimates (the REVEAL Study)[2][3] and one of the first prospective studies of direct-to-consumergenetic testing services (the PGen Study).[4] He has studied the implementation of medical sequencing in healthy adults (the MedSeq Project), newborns (the BabySeq Project),[5][6][7] and active duty military personnel (the MilSeq Project).[8] As of 2020, he is leading the first research collaboration to explore return of genomic results and better understand penetrance in a population-based cohort of underrepresented minorities.[9] He has led the Preventive Genomics Clinic atBrigham and Women's Hospital since its creation in 2019.[10]
Green served as principal investigator of the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) Study,[14] which explored the behavioral, and health-related impact of disclosing genetic risk for Alzheimer's disease. The study was a series of multi-site, randomized, controlled clinical trials that provide empirical data to address ethical, social and translational issues in genetic susceptibility testing for common diseases.[15][16][17]
Green also co-led (with J. Scott Roberts, Ph.D.) the Impact of Personal Genomics (PGen) Study, one of the first to investigate the characteristics of consumers; the behavioral and health impact; and the translational and social issues associated with personal genomic testing services.[4] He co-led the incidental findings working group for theAmerican College of Medical Genetics and Genomics and was lead author on the controversial recommendations for reporting incidental and secondary findings in clinical exome and genome sequencing.[18] Green also contributed to the design of a variant classification pipeline,[19] and a single page summary for reporting clinically relevant results of whole genome sequencing to physicians.[20][6]
Green currently leads and co-leads the firstNIH funded randomized trials of sequencing in adults (MedSeq Project), newborns (BabySeq Project), and active duty US military personnel (MilSeq Project). With continuous funding from NIH for 26 years, he has published more than 300 papers with an h index of 90.[21]
Green co-chaired the steering committee of both the Clinical Sequencing Exploratory Research program (18 NIH grants, over 300 investigators),[22] and the steering committee of the Newborn Sequencing in Genomic Medicine and Public Health program (4 NIH grants, over 100 investigators).[23] He is a currently a co-investigator on the Boston site within theElectronic Medical Records and Genomics Network (eMERGE). He is Associate Director for Research ofPartners HealthCare Personalized Medicine,[24] and is leading the development of protocols for return of genomic results for theAll of Us (initiative) Research Program of the United States Precision Medicine Initiative and the Google/Verily ProjectBaseline Study.[25]
Green directs the Genomes2People Research Program at Brigham Health and is the founding director of theBrigham Preventive Genomics Clinic.[26] He is Associate Director for Research of Partners HealthCare Personalized Medicine and a member of the executive committee for the Partners BioBank.[15] He is a board member of theCouncil for Responsible Genetics.[27] He was previously co-chair of the steering committee of the NIH Consortium in Newborn Sequencing in Genomic Medicine and Public Health (NSIGHT).[5] Green is a member of the Consortium on Electronic Medical Records and Genomics (eMERGE).[28] He served on the Institute of Medicine Committee on the "Evidence Base for Genetic Testing," and has collaborated on research studies withIllumina (company), 23andMe, Pathway and Google.[29][30][31]
Green received the 2014 Coriell Award for Scientific Achievement in Personalized Medicine.[32] BIS Research named Green one of the 25 most influential voices in precision medicine in 2019.[33]
^Jun, G.; Ibrahim-Verbaas, C. A.; Vronskaya, M.; Lambert, J.-C.; Chung, J.; Naj, A. C.; Kunkle, B. W.; Wang, L.-S.; Bis, J. C.; Bellenguez, C.; Harold, D.; Lunetta, K. L.; Destefano, A. L.; Grenier-Boley, B.; Sims, R.; Beecham, G. W.; Smith, A. V.; Chouraki, V.; Hamilton-Nelson, K. L.; Ikram, M. A.; Fievet, N.; Denning, N.; Martin, E. R.; Schmidt, H.; Kamatani, Y.; Dunstan, M. L.; Valladares, O.; Laza, A. R.; Zelenika, D.; et al. (January 2016)."A novel Alzheimer disease locus located near the gene encoding tau protein".Molecular Psychiatry.21 (1):108–117.doi:10.1038/mp.2015.23.PMC4573764.PMID25778476.
^Green, Robert C.; Roberts, J. Scott; Cupples, L. Adrienne; Relkin, Norman R.; Whitehouse, Peter J.; Brown, Tamsen; Eckert, Susan LaRusse; Butson, Melissa; Sadovnick, A. Dessa; Quaid, Kimberly A.; Chen, Clara; Cook-Deegan, Robert; Farrer, Lindsay A. (2009-07-16)."Disclosure ofAPOEGenotype for Risk of Alzheimer's Disease"(PDF).New England Journal of Medicine.361 (3). Massachusetts Medical Society:245–254.doi:10.1056/nejmoa0809578.ISSN0028-4793.
^Green, Robert C.; Goddard, Katrina A. B.; Jarvik, Gail P.; Amendola, Laura M.; Appelbaum, Paul S.; Berg, Jonathan S.; Bernhardt, Barbara A.; Biesecker, Leslie G.; Biswas, Sawona; Blout, Carrie L.; Bowling, Kevin M.; Brothers, Kyle B.; Burke, Wylie; Caga-anan, Charlisse F.; Chinnaiyan, Arul M.; Chung, Wendy K.; Clayton, Ellen W.; Cooper, Gregory M.; East, Kelly; Evans, James P.; Fullerton, Stephanie M.; Garraway, Levi A.; Garrett, Jeremy R.; Gray, Stacy W.; Henderson, Gail E.; Hindorff, Lucia A.; Holm, Ingrid A.; Lewis, Michelle Huckaby; Hutter, Carolyn M.; Janne, Pasi A.; Joffe, Steven; Kaufman, David; Knoppers, Bartha M.; Koenig, Barbara A.; Krantz, Ian D.; Manolio, Teri A.; McCullough, Laurence; McEwen, Jean; McGuire, Amy; Muzny, Donna; Myers, Richard M.; Nickerson, Deborah A.; Ou, Jeffrey; Parsons, Donald W.; Petersen, Gloria M.; Plon, Sharon E.; Rehm, Heidi L.; Roberts, J. Scott; Robinson, Dan; Salama, Joseph S.; Scollon, Sarah; Sharp, Richard R.; Shirts, Brian; Spinner, Nancy B.; Tabor, Holly K.; Tarczy-Hornoch, Peter; Veenstra, David L.; Wagle, Nikhil; Weck, Karen; Wilfond, Benjamin S.; Wilhelmsen, Kirk; Wolf, Susan M.; Wynn, Julia; Yu, Joon-Ho; Amaral, Michelle; Amendola, Laura; Appelbaum, Paul S.; Aronson, Samuel J.; Arora, Shubhangi; Azzariti, Danielle R.; Barsh, Greg S.; Bebin, E. M.; Biesecker, Barbara B.; Biesecker, Leslie G.; Biswas, Sawona; Blout, Carrie L.; Bowling, Kevin M.; Brothers, Kyle B.; Brown, Brian L.; Burt, Amber A.; Byers, Peter H.; Caga-anan, Charlisse F.; Calikoglu, Muge G.; Carlson, Sara J.; Chahin, Nizar; Chinnaiyan, Arul M.; Christensen, Kurt D.; Chung, Wendy; Cirino, Allison L.; Clayton, Ellen; Conlin, Laura K.; Cooper, Greg M.; Crosslin, David R.; Davis, James V.; Davis, Kelly; Deardorff, Matthew A.; Devkota, Batsal; De Vries, Raymond; Diamond, Pamela; Dorschner, Michael O.; Dugan, Noreen P.; Dukhovny, Dmitry; Dulik, Matthew C.; East, Kelly M.; Rivera-Munoz, Edgar A.; Evans, Barbara; Evans, James P.; Everett, Jessica; Exe, Nicole; Fan, Zheng; Feuerman, Lindsay Z.; Filipski, Kelly; Finnila, Candice R.; Fishler, Kristen; Fullerton, Stephanie M.; Ghrundmeier, Bob; Giles, Karen; Gilmore, Marian J.; Girnary, Zahra S.; Goddard, Katrina; Gonsalves, Steven; Gordon, Adam S.; Gornick, Michele C.; Grady, William M.; Gray, David E.; Gray, Stacy W.; Green, Robert; Greenwood, Robert S.; Gutierrez, Amanda M.; Han, Paul; Hart, Ragan; Heagerty, Patrick; Henderson, Gail E.; Hensman, Naomi; Hiatt, Susan M.; Himes, Patricia; Hindorff, Lucia A.; Hisama, Fuki M.; Ho, Carolyn Y.; Hoffman-Andrews, Lily B.; Holm, Ingrid A.; Hong, Celine; Horike-Pyne, Martha J.; Hull, Sara; Hutter, Carolyn M.; Jamal, Seema; Jarvik, Gail P.; Jensen, Brian C.; Joffe, Steve; Johnston, Jennifer; Karavite, Dean; Kauffman, Tia L.; Kaufman, Dave; Kelley, Whitley; Kim, Jerry H.; Kirby, Christine; Klein, William; Knoppers, Bartha; Koenig, Barbara A.; Kong, Sek Won; Krantz, Ian; Krier, Joel B.; Lamb, Neil E.; Lambert, Michele P.; Le, Lan Q.; Lebo, Matthew S.; Lee, Alexander; Lee, Kaitlyn B.; Lennon, Niall; Leo, Michael C.; Leppig, Kathleen A.; Lewis, Katie; Lewis, Michelle; Lindeman, Neal I.; Lockhart, Nicole; Lonigro, Bob; Lose, Edward J.; Lupo, Philip J.; Rodriguez, Laura Lyman; Lynch, Frances; Machini, Kalotina; MacRae, Calum; Manolio, Teri A.; Marchuk, Daniel S.; Martinez, Josue N.; Masino, Aaron; McCullough, Laurence; McEwen, Jean; McGuire, Amy; McLaughlin, Heather M.; McMullen, Carmit; Mieczkowski, Piotr A.; Miller, Jeff; Miller, Victoria A.; Mody, Rajen; Mooney, Sean D.; Moore, Elizabeth G.; Morris, Elissa; Murray, Michael; Muzny, Donna; Myers, Richard M.; Ng, David; Nickerson, Deborah A.; Oliver, Nelly M.; Ou, Jeffrey; Parsons, Will; Patrick, Donald L.; Pennington, Jeffrey; Perry, Denise L.; Petersen, Gloria; Plon, Sharon; Porter, Katie; Powell, Bradford C.; Punj, Sumit; Breitkopf, Carmen Radecki; Raesz-Martinez, Robin A.; Raskind, Wendy H.; Rehm, Heidi L.; Reigar, Dean A.; Reiss, Jacob A.; Rich, Carla A.; Richards, Carolyn Sue; Rini, Christine; Roberts, Scott; Robertson, Peggy D.; Robinson, Dan; Robinson, Jill O.; Robinson, Marguerite E.; Roche, Myra I.; Romasko, Edward J.; Rosenthal, Elisabeth A.; Salama, Joseph; Scarano, Maria I.; Schneider, Jennifer; Scollon, Sarah; Seidman, Christine E.; Seifert, Bryce A.; Sharp, Richard R.; Shirts, Brian H.; Sholl, Lynette M.; Siddiqui, Javed; Silverman, Elian; Simmons, Shirley; Simons, Janae V.; Skinner, Debra; Spinner, Nancy B.; Stoffel, Elena; Strande, Natasha T.; Sunyaev, Shamil; Sybert, Virginia P.; Taber, Jennifer; Tabor, Holly K.; Tarczy-Hornoch, Peter; Taylor, Deanne M.; Tilley, Christian R.; Tomlinson, Ashley; Trinidad, Susan; Tsai, Ellen; Ubel, Peter; Van Allen, Eliezer M.; Vassy, Jason L.; Vats, Pankaj; Veenstra, David L.; Vetter, Victoria L.; Vries, Raymond D.; Wagle, Nikhil; Walser, Sarah A.; Walsh, Rebecca C.; Weck, Karen; Werner-Lin, Allison; Whittle, Jana; Wilfond, Ben; Wilhelmsen, Kirk C.; Wolf, Susan M.; Wynn, Julia; Yang, Yaping; Young, Carol; Yu, Joon-Ho; Zikmund-Fisher, Brian J. (2 June 2016)."Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine".The American Journal of Human Genetics.98 (6):1051–1066.doi:10.1016/j.ajhg.2016.04.011.PMC4908179.PMID27181682.
^Berg, Jonathan S.; Agrawal, Pankaj B.; Bailey, Donald B.; Beggs, Alan H.; Brenner, Steven E.; Brower, Amy M.; Cakici, Julie A.; Ceyhan-Birsoy, Ozge; Chan, Kee; Chen, Flavia; Currier, Robert J.; Dukhovny, Dmitry; Green, Robert C.; Harris-Wai, Julie; Holm, Ingrid A.; Iglesias, Brenda; Joseph, Galen; Kingsmore, Stephen F.; Koenig, Barbara A.; Kwok, Pui-Yan; Lantos, John; Leeder, Steven J.; Lewis, Megan A.; McGuire, Amy L.; Milko, Laura V.; Mooney, Sean D.; Parad, Richard B.; Pereira, Stacey; Petrikin, Joshua; Powell, Bradford C.; Powell, Cynthia M.; Puck, Jennifer M.; Rehm, Heidi L.; Risch, Neil; Roche, Myra; Shieh, Joseph T.; Veeraraghavan, Narayanan; Watson, Michael S.; Willig, Laurel; Yu, Timothy W.; Urv, Tiina; Wise, Anastasia L. (1 February 2017)."Newborn Sequencing in Genomic Medicine and Public Health".Pediatrics.139 (2): e20162252.doi:10.1542/peds.2016-2252.PMC5260149.PMID28096516.
