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Richard J. Roberts

From Wikipedia, the free encyclopedia
British biochemist (born 1943)

Richard J. Roberts
Roberts in 2007
Born
Richard John Roberts

(1943-09-06)6 September 1943 (age 82)[3]
Derby, England
Alma materUniversity of Sheffield (BSc,PhD)
Known for
Awards
Scientific career
FieldsMolecular biology
Institutions
ThesisPhytochemical studies involving neoflavanoids and isoflavanoids (1969)
Websitenobelprize.org/nobel_prizes/medicine/laureates/1993/roberts-bio.html

Sir Richard John Roberts (born 6 September 1943) is a Britishbiochemist andmolecular biologist. He was awarded the 1993Nobel Prize in Physiology or Medicine withPhillip Allen Sharp for the discovery ofintrons ineukaryoticDNA and the mechanism ofgene-splicing. He currently works atNew England Biolabs.[6][7][8]

Early life and education

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Roberts was born inDerby, the son of Edna (Allsop) and John Roberts, an auto mechanic.[9] When he was four, Roberts' family moved toBath. In Bath, he attendedCity of Bath Boys' School.[9] As a child he at first wanted to be adetective and then, when given achemistry set, achemist. In 1965 he graduated from theUniversity of Sheffield with aBachelor of Science degree inchemistry followed by aPhD in 1969.[3] His thesis involvedphytochemical studies ofneoflavonoids andisoflavonoids.[10][11]

Career and research

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During 1969–1972, he didpostdoctoral research atHarvard University.[9] before moving toCold Spring Harbor Laboratory,[12] where he was hired byJames Dewey Watson, a co-discoverer of the structure ofDNA and a fellow Nobel laureate. In this period he also visited theMRC Laboratory of Molecular Biology for the first time, working alongsideFred Sanger.[13] In 1977, he published his discovery of RNA splicing.[12] In 1992, he moved toNew England Biolabs.[9] The following year, he shared a Nobel Prize with his former colleague at Cold Spring HarborPhillip Allen Sharp.[14]

Roberts's discovery of thealternative splicing of genes, in particular, has had a profound impact on the study and applications of molecular biology.[15] The realisation that individual genes could exist as separate, disconnected segments within longer strands of DNA first arose in his 1977 study ofadenovirus,[12] one of the viruses responsible for causing the common cold. Robert's research in this field resulted in a fundamental shift in our understanding ofgenetics, and has led to the discovery of split genes in higher organisms, including human beings.[15][8]

Awards and honours

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In 1992, Roberts received anhonorary doctorate from the Faculty of Medicine atUppsala University,Sweden.[16] After becoming a Nobel laureate in 1993 he was awarded an Honorary Degree (Doctor of Science) by theUniversity of Bath in 1994.[17] Roberts also received the Golden Plate Award of theAmerican Academy of Achievement in 1994.[18] In 2021 he was awarded theLomonosov Gold Medal of theRussian Academy of Sciences.[4] In 2025, he became anhonorary member of theacademic staff ofD'Annunzio University of Chieti–Pescara,Italy.[19]

Roberts was elected aFellow of the Royal Society (FRS) in 1995[15] and amember of the European Molecular Biology Organization (EMBO) in the same year.[20] In 2005, a multimillion-pound expansion to the chemistry department at theUniversity of Sheffield, where he had been a student, was named after him. A refurbished science department atBeechen Cliff School (previously City of Bath Boys' School) was also named after Roberts, who had donated a substantial sum of his Nobel prize winnings to the school.[21]

Roberts is an atheist and was one of the signers of theHumanist Manifesto.[22][23] He wasknighted in the 2008 Birthday Honours.[24]

Roberts is a member of the Advisory Board ofPatient Innovation,[25] a nonprofit, international, multilingual, free venue for patients and caregivers of any disease to share their innovations.

Roberts has been akeynote speaker at the Congress of Future Medical Leaders (2014, 2015, 2016, 2020).[26]

He also is the chairman of The Laureate Science Alliance, a non-profit supporting research worldwide.

In 2016, Roberts and other Nobelists composed and signed a "Laureates Letter Supporting Precision Agriculture (GMOs)" addressed to the leaders of Greenpeace, the United Nations and global governments and Sir Roberts has advocated forGenetically Modified Organisms (GMOs) in general andGolden Rice in particular to advance health in developing countries, noting the high safety record of GM foods.[27][28]

References

[edit]
Scholia has anauthor profile forRichard J. Roberts.
  1. ^Shampo, M. A.; Kyle, R. A. (2003)."Richard J. Roberts—Nobel Laureate for Discovery of Split Genes".Mayo Clinic Proceedings.78 (2): 132.doi:10.4065/78.2.132.PMID 12583523.
  2. ^Carr, Kimberly (1993)."Nobel goes to discoverers of 'split genes'".Nature.365 (6447): 597.Bibcode:1993Natur.365..597C.doi:10.1038/365597a0.PMID 8413620.
  3. ^abcd"ROBERTS,Sir Richard (John)".Who's Who. Vol. 1995 (onlineOxford University Press ed.). A & C Black.(Subscription orUK public library membership required.)
  4. ^abLomonosov Gold Medal 2021(in Russian)
  5. ^Roberts, Richard John (2003)."A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes".Nucleic Acids Research.31 (7):1805–1812.doi:10.1093/nar/gkg274.PMC 152790.PMID 12654995.Open access icon
  6. ^Roberts, R. J.; Chang, Y. -C.; Hu, Z.; Rachlin, J. N.; Anton, B. P.; Pokrzywa, R. M.; Choi, H. -P.; Faller, L. L.; Guleria, J.; Housman, G.; Klitgord, N.; Mazumdar, V.; McGettrick, M. G.; Osmani, L.; Swaminathan, R.; Tao, K. R.; Letovsky, S.; Vitkup, D.; Segrè, D.; Salzberg, S. L.; Delisi, C.; Steffen, M.; Kasif, S. (2010)."COMBREX: A project to accelerate the functional annotation of prokaryotic genomes".Nucleic Acids Research.39 (Database issue):D11 –D14.doi:10.1093/nar/gkq1168.PMC 3013729.PMID 21097892.
  7. ^Roberts, R. J.;Varmus, H. E.;Ashburner, M.;Brown, P. O.;Eisen, M. B.;Khosla, C.; Kirschner, M.;Nusse, R.; Scott, M. (2001). "Information Access: Building AGenBank of the Published Literature".Science.291 (5512):2318–9.doi:10.1126/science.1060273.PMID 11269300.S2CID 34395787.
  8. ^abRichard J. Roberts's publications indexed by theScopus bibliographic database.(subscription required)
  9. ^abcdAnon (1993)."Richard J. Roberts - Biographical". Nobel Foundation. Archived fromthe original on 4 March 2016. Retrieved28 February 2016.
  10. ^Roberts, Richard John (1969).Phytochemical studies involving neoflavanoids and isoflavanoids.copac.jisc.ac.uk (PhD thesis). University of Sheffield.OCLC 270832404. Archived fromthe original on 14 November 2017. Retrieved13 November 2017.
  11. ^Richard J. RobertsORCID 0000-0002-4348-0169
  12. ^abcChow, Louise T.; Gelinas, Richard E.; Broker, Thomas R.; Roberts, Richard J. (1977). "An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA".Cell.12 (1):1–8.doi:10.1016/0092-8674(77)90180-5.PMID 902310.S2CID 2099968.
  13. ^"The Nobel Prize in Physiology or Medicine 1993".NobelPrize.org. Retrieved14 July 2023.
  14. ^Klimasauskas, Saulius; Kumar, Sanjay; Roberts, Richard J.; Cheng, Xiaodong (1994). "Hhal methyltransferase flips its target base out of the DNA helix".Cell.76 (2):357–369.doi:10.1016/0092-8674(94)90342-5.PMID 8293469.S2CID 23161543.
  15. ^abcAnon (1995)."Sir Richard Roberts FRS". London:Royal Society. Archived fromthe original on 6 October 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available underCreative Commons Attribution 4.0 International License.” --"Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved9 March 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link)

  16. ^"Honorary doctorates - Uppsala University, Sweden".Uu.se. 17 August 2016. Retrieved28 August 2016.
  17. ^"Honorary Graduates 1989 to present".bath.ac.uk.University of Bath. Archived fromthe original on 19 December 2015. Retrieved18 February 2012.
  18. ^"Golden Plate Awardees of the American Academy of Achievement".achievement.org.American Academy of Achievement.
  19. ^ANSA, ed. (10 September 2025)."Il Nobel Roberts membro onorario dell'Università D'Annunzio" [Nobel Prize winner Roberts honorary member of D'Annunzio University] (in Italian). Retrieved22 September 2025.
  20. ^Anon (2016)."Richard J. Roberts EMBO profile".people.embo.org. Heidelberg:European Molecular Biology Organization.
  21. ^"Beechen Cliff School website".[dead link]
  22. ^"Humanist Manifesto II". American Humanist Association. Archived fromthe original on 20 October 2012. Retrieved4 October 2012.
  23. ^Reville, William (2006)."A bright journey to atheism, or a road that ignores all the signs?".The Irish Times. Dublin. Archived fromthe original on 5 March 2016.
  24. ^"Queen's Birthday Honours: Full list | the Independent".The Independent. 13 June 2008.
  25. ^Patient Innovation
  26. ^"Speakers".Congress of Future Medical Leaders. Retrieved31 March 2020.
  27. ^Keith Edmisten (9 July 2018).""GMOs Are Vital Against Hunger," Says Nobel Laureate Sir Richard J. Roberts".
  28. ^Ed Regis (8 October 2019).Golden Rice: The Imperiled Birth of a GMO Superfood. Johns Hopkins University Press.ISBN 978-1421433035.

External links

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  • Richard J. Roberts on Nobelprize.orgEdit this at Wikidata including the Nobel LectureAn Amazing Distortion in DNA Induced by a Methyltransferase
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