 | |
| Names | |
|---|---|
| IUPAC name Methyl (7R,16E)-17-methoxy-2-oxo-16,17-didehydro-20α-corynoxan-16-carboxylate | |
| Systematic IUPAC name Methyl (2E)-2-[(1′R,6′R,7′S,8a′S)-6′-ethyl-2-oxo-1,2,2′,3′,6′,7′,8′,8a′-octahydro-5′H-spiro[indole-3,1′-indolizin]-7′-yl]-3-methoxyprop-2-enoate | |
Other names
| |
| Identifiers | |
| |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.208.612 |
| KEGG | |
| UNII | |
| |
| |
| Properties | |
| C22H28N2O4 | |
| Molar mass | 384.476 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Rhynchophylline is analkaloid found in certainUncaria species (Rubiaceae), notablyUncaria rhynchophylla[1] andUncaria tomentosa.[2] It also occurs in the leaves ofMitragyna speciosa (kratom) and Mitragyna tubulosa,[3] a tree native to Thailand. Chemically, it is related to the alkaloidmitragynine.
Rhynchophylline is a non-competitiveNMDA antagonist (IC50 = 43.2 μM) and acalcium channel blocker.[4][5]
Uncaria species have had a variety of uses intraditional herbal medicine, such as for lightheadedness, convulsions, numbness, and hypertension.[6] These uses have been associated with the presence of rhynchophylline and have encouraged its investigation as a drug candidate for several cardiovascular and central nervous system diseases; however, few clinically relevant studies have been conducted.[6]
